(E)-methyl 5-fluoro-2-(3-(4-fluorophenyl)-2-(1-methyl-1H-1,2,4-triazol-5-yl)acryloyl)-3-nitrobenzoate

Base Information

Chemical Name:(E)-methyl 5-fluoro-2-(3-(4-fluorophenyl)-2-(1-methyl-1H-1,2,4-triazol-5-yl)acryloyl)-3-nitrobenzoate
CAS No.:1322616-39-6
Molecular Formula:C₂₀H₁₄F₂N₄O₅
Molecular Weight:428.352
Hs Code.:

Synonyms:(E)-methyl 5-fluoro-2-(3-(4-fluorophenyl)-2-(1-methyl-1H-1,2,4-triazol-5-yl)acryloyl)-3-nitrobenzoate

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Chemical Property of (E)-methyl 5-fluoro-2-(3-(4-fluorophenyl)-2-(1-methyl-1H-1,2,4-triazol-5-yl)acryloyl)-3-nitrobenzoate

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Technology Process of (E)-methyl 5-fluoro-2-(3-(4-fluorophenyl)-2-(1-methyl-1H-1,2,4-triazol-5-yl)acryloyl)-3-nitrobenzoate

There total 3 articles about (E)-methyl 5-fluoro-2-(3-(4-fluorophenyl)-2-(1-methyl-1H-1,2,4-triazol-5-yl)acryloyl)-3-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: methyl 5-fluoro-2-(2-(1-methyl-1H-1,2,4-triazole-3-yl)acetyl)-3-nitrobenzoate hydrochloride

: 459-57-4
4-fluorobenzaldehyde

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 1322616-39-6
(E)-methyl 5-fluoro-2-(3-(4-fluorophenyl)-2-(1-methyl-1H-1,2,4-triazol-5-yl)acryloyl)-3-nitrobenzoate

Guidance literature:: In dimethyl sulfoxide; at 45 ℃; for 48h;

Reference yield:

: 1207453-90-4
6-fluoro-4-nitroisobenzofuran-1(3H)-one

: 1322616-39-6
(E)-methyl 5-fluoro-2-(3-(4-fluorophenyl)-2-(1-methyl-1H-1,2,4-triazol-5-yl)acryloyl)-3-nitrobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic anhydride; triethylamine / dichloromethane; 2-methyltetrahydrofuran / 20 - 95 °C / Industry scale

2: hydrogenchloride / methanol / 25 h / 20 °C

3: dimethyl sulfoxide / 48 h / 45 °C

With hydrogenchloride; acetic anhydride; triethylamine; In 2-methyltetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1322616-34-1
(Z)-6-fluoro-3-((1-methyl-1H-1,2,4-triazol-5-yl)methylene)-4-nitroisobenzofuran-1(3H)-one

: 1322616-39-6
(E)-methyl 5-fluoro-2-(3-(4-fluorophenyl)-2-(1-methyl-1H-1,2,4-triazol-5-yl)acryloyl)-3-nitrobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / methanol / 25 h / 20 °C

2: dimethyl sulfoxide / 48 h / 45 °C

With hydrogenchloride; In methanol; dimethyl sulfoxide;