N-(6-(4-(5-amino-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)-2-(3-(trifluoromethoxy)phenyl)acetamide

Base Information

• Chemical Name: N-(6-(4-(5-amino-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)-2-(3-(trifluoromethoxy)phenyl)acetamide
• CAS No.: 1439399-45-7
• Molecular Formula: C₁₉H₁₉F₃N₆O₂S
• Molecular Weight: 452.46
• Mol file: 1439399-45-7.mol

Synonyms:N-(6-(4-(5-amino-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)-2-(3-(trifluoromethoxy)phenyl)acetamide

Chemical Property of N-(6-(4-(5-amino-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)-2-(3-(trifluoromethoxy)phenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(6-(4-(5-amino-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)-2-(3-(trifluoromethoxy)phenyl)acetamide

There total 3 articles about N-(6-(4-(5-amino-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)-2-(3-(trifluoromethoxy)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-(6-(4-cyanobutyl)pyridazin-3-yl)-2-(3-(trifluoromethoxy)phenyl)acetamide (1439400-48-2) + thiosemicarbazide (79-19-6) → N-(6-(4-(5-amino-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)-2-(3-(trifluoromethoxy)phenyl)acetamide (1439399-45-7)

Guidance literature:

With trifluoroacetic acid; at 65 ℃; for 5h;

Reference yield:

2-(3-(trifluoromethoxy)phenyl)acetic acid (203302-97-0) → N-(6-(4-(5-amino-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)-2-(3-(trifluoromethoxy)phenyl)acetamide (1439399-45-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 30 °C

2: 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / 5 h / 65 °C

With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

N-(6-chloropyridazin-3-yl)-2-(3-(trifluoromethoxy)phenyl)acetamide (1439400-46-0) → N-(6-(4-(5-amino-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)-2-(3-(trifluoromethoxy)phenyl)acetamide (1439399-45-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid / 5 h / 65 °C

With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); trifluoroacetic acid; In tetrahydrofuran;

upstream raw materials:

2-(3-(trifluoromethoxy)phenyl)acetic acid

N-(6-chloropyridazin-3-yl)-2-(3-(trifluoromethoxy)phenyl)acetamide

N-(6-(4-cyanobutyl)pyridazin-3-yl)-2-(3-(trifluoromethoxy)phenyl)acetamide

thiosemicarbazide

Downstream raw materials:

C₂₇H₂₄F₄N₆O₃S

C₂₅H₂₃F₃N₈O₃S

C₂₇H₂₅F₃N₆O₄S

C₃₅H₃₁F₃N₆O₆S