(2R,4R)-3-tert-butoxycarbonyl-2-(4-tert-butyldimethylsilyloxy-but-2-ynoil)-4-phenyl-1,3-oxazolidine

Base Information

Chemical Name:(2R,4R)-3-tert-butoxycarbonyl-2-(4-tert-butyldimethylsilyloxy-but-2-ynoil)-4-phenyl-1,3-oxazolidine
CAS No.:234122-92-0
Molecular Formula:C₂₄H₃₅NO₅Si
Molecular Weight:445.631
Hs Code.:

Synonyms:(2R,4R)-3-tert-butoxycarbonyl-2-(4-tert-butyldimethylsilyloxy-but-2-ynoil)-4-phenyl-1,3-oxazolidine

Suppliers and Price of (2R,4R)-3-tert-butoxycarbonyl-2-(4-tert-butyldimethylsilyloxy-but-2-ynoil)-4-phenyl-1,3-oxazolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4R)-3-tert-butoxycarbonyl-2-(4-tert-butyldimethylsilyloxy-but-2-ynoil)-4-phenyl-1,3-oxazolidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Pictogram(s):
Hazard Codes:

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Technology Process of (2R,4R)-3-tert-butoxycarbonyl-2-(4-tert-butyldimethylsilyloxy-but-2-ynoil)-4-phenyl-1,3-oxazolidine

There total 6 articles about (2R,4R)-3-tert-butoxycarbonyl-2-(4-tert-butyldimethylsilyloxy-but-2-ynoil)-4-phenyl-1,3-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 76782-82-6
tert-Butyldimethyl(prop-2-ynyloxy)silane

: 164530-43-2
Weinreb amide

: 234122-92-0
(2R,4R)-3-tert-butoxycarbonyl-2-(4-tert-butyldimethylsilyloxy-but-2-ynoil)-4-phenyl-1,3-oxazolidine

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -10 ℃; for 2h;
DOI:10.1016/S0040-4020(99)00949-7

Reference yield: 75.0%

: 91509-32-9
3-(t-butyldimethylsilyloxy)prop-1-ynyllithium

: 164530-43-2
Weinreb amide

: 234122-92-0
(2R,4R)-3-tert-butoxycarbonyl-2-(4-tert-butyldimethylsilyloxy-but-2-ynoil)-4-phenyl-1,3-oxazolidine

Guidance literature:: In tetrahydrofuran; -78 deg C to RT;
DOI:10.1016/S0040-4039(99)00800-X

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 234122-92-0
(2R,4R)-3-tert-butoxycarbonyl-2-(4-tert-butyldimethylsilyloxy-but-2-ynoil)-4-phenyl-1,3-oxazolidine

Guidance literature:: Multi-step reaction with 3 steps

2: 1.) N-methyl morpholine, i-BuOCOCl; 2.) NEt₃ / 1.) THF; 2.) DMF, -20 deg C

3: tetrahydrofuran / -78 °C

With 4-methyl-morpholine; triethylamine; isobutyl chloroformate; In tetrahydrofuran;
DOI:10.1016/0040-4039(96)00767-8