Technology Process of 3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-8-phenyl-9-(4-methoxyphenyl)-5H-benzocycloheptene
There total 4 articles about 3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-8-phenyl-9-(4-methoxyphenyl)-5H-benzocycloheptene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
phenyllithium;
With
zinc(II) chloride;
In
tetrahydrofuran; dibutyl ether;
at 20 ℃;
for 0.5h;
Inert atmosphere;
3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-8-bromo-9-(4-methoxyphenyl)-5H-benzocycloheptene;
With
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dibutyl ether;
at 20 ℃;
for 3h;
Inert atmosphere;
Reflux;
DOI:10.1021/jm500569h
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 20 °C / Inert atmosphere
2.1: diethyl ether; tetrahydrofuran / 12 h / 20 °C / Inert atmosphere; Reflux
2.2: 2 h / Inert atmosphere; Reflux
3.1: pyridinium hydrobromide perbromide / dichloromethane / 20 h / 20 °C / Inert atmosphere
4.1: zinc(II) chloride / tetrahydrofuran; dibutyl ether / 0.5 h / 20 °C / Inert atmosphere
4.2: 3 h / 20 °C / Inert atmosphere; Reflux
With
tetra(n-butyl)ammonium hydrogensulfate; pyridinium hydrobromide perbromide; sodium hydroxide; zinc(II) chloride;
In
tetrahydrofuran; diethyl ether; dichloromethane; dibutyl ether; water;
DOI:10.1021/jm500569h
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: aluminum (III) chloride / toluene / Reflux
2.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 20 °C / Inert atmosphere
3.1: diethyl ether; tetrahydrofuran / 12 h / 20 °C / Inert atmosphere; Reflux
3.2: 2 h / Inert atmosphere; Reflux
4.1: pyridinium hydrobromide perbromide / dichloromethane / 20 h / 20 °C / Inert atmosphere
5.1: zinc(II) chloride / tetrahydrofuran; dibutyl ether / 0.5 h / 20 °C / Inert atmosphere
5.2: 3 h / 20 °C / Inert atmosphere; Reflux
With
aluminum (III) chloride; tetra(n-butyl)ammonium hydrogensulfate; pyridinium hydrobromide perbromide; sodium hydroxide; zinc(II) chloride;
In
tetrahydrofuran; diethyl ether; dichloromethane; dibutyl ether; water; toluene;
DOI:10.1021/jm500569h
