4-(dimethylamino)-3-(2-hydroxyethyl)benzyl 5-(1,2-dithiolan-3-yl)pentanoate

Base Information

Chemical Name:4-(dimethylamino)-3-(2-hydroxyethyl)benzyl 5-(1,2-dithiolan-3-yl)pentanoate
CAS No.:1450602-67-1
Molecular Formula:C₁₉H₂₉NO₃S₂
Molecular Weight:383.576
Hs Code.:

Synonyms:4-(dimethylamino)-3-(2-hydroxyethyl)benzyl 5-(1,2-dithiolan-3-yl)pentanoate

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Chemical Property of 4-(dimethylamino)-3-(2-hydroxyethyl)benzyl 5-(1,2-dithiolan-3-yl)pentanoate

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Technology Process of 4-(dimethylamino)-3-(2-hydroxyethyl)benzyl 5-(1,2-dithiolan-3-yl)pentanoate

There total 6 articles about 4-(dimethylamino)-3-(2-hydroxyethyl)benzyl 5-(1,2-dithiolan-3-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1450602-71-7
C₂₅H₄₃NO₃S₂Si

: 1450602-67-1
4-(dimethylamino)-3-(2-hydroxyethyl)benzyl 5-(1,2-dithiolan-3-yl)pentanoate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1002/ejoc.201300339

Reference yield:

: 1399672-04-8
2-[5-bromo-2-(N,N-dimethylamino)phenyl]ethanol

: 1450602-67-1
4-(dimethylamino)-3-(2-hydroxyethyl)benzyl 5-(1,2-dithiolan-3-yl)pentanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / dichloromethane / 20 °C

2.1: n-butyllithium / tetrahydrofuran / -78 - 0 °C / Inert atmosphere

2.2: 2 h / -78 - 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate / methanol / 2.5 h / 60 °C

4.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 24 h / 20 °C / Cooling

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; n-butyllithium; tetrabutyl ammonium fluoride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/ejoc.201300339

Reference yield:

: 5339-27-5
2-(2-dimethylaminophenyl)ethyl alcohol

: 1450602-67-1
4-(dimethylamino)-3-(2-hydroxyethyl)benzyl 5-(1,2-dithiolan-3-yl)pentanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium acetate; N-Bromosuccinimide / acetonitrile / 20 °C

2.1: 1H-imidazole / dichloromethane / 20 °C

3.1: n-butyllithium / tetrahydrofuran / -78 - 0 °C / Inert atmosphere

3.2: 2 h / -78 - 20 °C / Inert atmosphere

4.1: sodium tetrahydroborate / methanol / 2.5 h / 60 °C

5.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 24 h / 20 °C / Cooling

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; N-Bromosuccinimide; n-butyllithium; ammonium acetate; tetrabutyl ammonium fluoride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1002/ejoc.201300339