(1'R,2'R)-(Z)-2-(2'-t-butyldimethylsiloxymethyl-1',2'-dimethylcyclopentylmethyl)-2-ethoxyethoxy-6-<2,5-bis(methoxymethoxy)-3-methylphenyl>-4-methyl-4-hexenonitrile

Base Information

Chemical Name:(1'R*,2'R*)-(Z)-2-(2'-t-butyldimethylsiloxymethyl-1',2'-dimethylcyclopentylmethyl)-2-ethoxyethoxy-6-<2,5-bis(methoxymethoxy)-3-methylphenyl>-4-methyl-4-hexenonitrile
CAS No.:125318-34-5
Molecular Formula:C₃₇H₆₃NO₇Si
Molecular Weight:661.995
Hs Code.:

(1'R*,2'R*)-(Z)-2-(2'-t-butyldimethylsiloxymethyl-1',2'-dimethylcyclopentylmethyl)-2-ethoxyethoxy-6-<2,5-bis(methoxymethoxy)-3-methylphenyl>-4-methyl-4-hexenonitrile

Synonyms:(1'R*,2'R*)-(Z)-2-(2'-t-butyldimethylsiloxymethyl-1',2'-dimethylcyclopentylmethyl)-2-ethoxyethoxy-6-<2,5-bis(methoxymethoxy)-3-methylphenyl>-4-methyl-4-hexenonitrile

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Chemical Property of (1'R*,2'R*)-(Z)-2-(2'-t-butyldimethylsiloxymethyl-1',2'-dimethylcyclopentylmethyl)-2-ethoxyethoxy-6-<2,5-bis(methoxymethoxy)-3-methylphenyl>-4-methyl-4-hexenonitrile

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Technology Process of (1'R*,2'R*)-(Z)-2-(2'-t-butyldimethylsiloxymethyl-1',2'-dimethylcyclopentylmethyl)-2-ethoxyethoxy-6-<2,5-bis(methoxymethoxy)-3-methylphenyl>-4-methyl-4-hexenonitrile

There total 48 articles about (1'R*,2'R*)-(Z)-2-(2'-t-butyldimethylsiloxymethyl-1',2'-dimethylcyclopentylmethyl)-2-ethoxyethoxy-6-<2,5-bis(methoxymethoxy)-3-methylphenyl>-4-methyl-4-hexenonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 125318-19-6
(1'R*,2'R*)-3-(2'-t-butyldimethylsiloxymethyl-1',2'-dimethylcyclopentyl)-2-(ethoxyethoxy)propionitrile

: 125318-20-9
(Z)-3-(4-chloro-3-methyl-2-butenyl)-2,5-bis(methoxymethoxy)toluene

: 125318-34-5
(1'R*,2'R*)-(Z)-2-(2'-t-butyldimethylsiloxymethyl-1',2'-dimethylcyclopentylmethyl)-2-ethoxyethoxy-6-<2,5-bis(methoxymethoxy)-3-methylphenyl>-4-methyl-4-hexenonitrile

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at 0 ℃; for 0.666667h;
DOI:10.1016/S0040-4020(01)80058-2

Reference yield: 63.0%

: 125318-21-0
(E)-3-(4-chloro-3-methyl-2-butenyl)-2,5-bis(methoxymethoxy)toluene

: 125318-19-6
(1'R*,2'R*)-3-(2'-t-butyldimethylsiloxymethyl-1',2'-dimethylcyclopentyl)-2-(ethoxyethoxy)propionitrile

: 125318-34-5
(1'R*,2'R*)-(E)-2-(2'-t-butyldimethylsiloxymethyl-1',2'-dimethylcyclopentylmethyl)-2-ethoxyethoxy-6-<2,5-bis(methoxymethoxy)-3-methylphenyl>-4-methyl-4-hexenonitrile

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1016/S0040-4020(01)80058-2

Reference yield:

: 6293-55-6
2-bromo-6-methyl-[1,4]benzoquinone

: 125318-34-5
(1'R*,2'R*)-(Z)-2-(2'-t-butyldimethylsiloxymethyl-1',2'-dimethylcyclopentylmethyl)-2-ethoxyethoxy-6-<2,5-bis(methoxymethoxy)-3-methylphenyl>-4-methyl-4-hexenonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: 38 percent / Na₂S₂O₄ / ethanol; H₂O / 1 h / 60 °C

2: 57 percent / Na / 2-methoxy-ethanol / Ambient temperature

3: 88 percent / n-BuLi, CuI / hexane; diethyl ether / Ambient temperature

4: 20 g / OsO₄, NaIO₄ / diethyl ether / 6 h / Ambient temperature

5: 21 percent / NaH / tetrahydrofuran / 0.5 h / -70 °C

6: 99 percent / LAH / diethyl ether / 1 h / Ambient temperature

7: 86 percent / PPh₃, CCl₄ / 20 h / Heating

8: 70 percent / n-BuLi, diisopropylamine / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.67 h / 0 °C

With tetrachloromethane; sodium periodate; copper(l) iodide; osmium(VIII) oxide; lithium aluminium tetrahydride; n-butyllithium; sodium dithionite; sodium; sodium hydride; diisopropylamine; triphenylphosphine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol; hexane; 2-methoxy-ethanol; water;
DOI:10.1016/S0040-4020(01)80058-2