N,N'-Bis-((1R,2S)-2-hydroxy-1,2-diphenyl-ethyl)-2,2-dimethyl-malonamide

Base Information

Chemical Name:N,N'-Bis-((1R,2S)-2-hydroxy-1,2-diphenyl-ethyl)-2,2-dimethyl-malonamide
CAS No.:183866-68-4
Molecular Formula:C₃₃H₃₄N₂O₄
Molecular Weight:522.644
Hs Code.:

Synonyms:N,N'-Bis-((1R,2S)-2-hydroxy-1,2-diphenyl-ethyl)-2,2-dimethyl-malonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N'-Bis-((1R,2S)-2-hydroxy-1,2-diphenyl-ethyl)-2,2-dimethyl-malonamide

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Technology Process of N,N'-Bis-((1R,2S)-2-hydroxy-1,2-diphenyl-ethyl)-2,2-dimethyl-malonamide

There total 1 articles about N,N'-Bis-((1R,2S)-2-hydroxy-1,2-diphenyl-ethyl)-2,2-dimethyl-malonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 23364-44-5
(1S,2R)-2-Amino-1,2-diphenylethanol

: 5659-93-8
2,2-Dimethylmalonyl chloride

: 183866-68-4
N,N'-Bis-((1R,2S)-2-hydroxy-1,2-diphenyl-ethyl)-2,2-dimethyl-malonamide

Guidance literature:: With triethylamine; In dichloromethane; Ambient temperature;
DOI:10.1016/0040-4020(96)00817-4

Reference yield: 80.0%

: 183866-68-4
N,N'-Bis-((1R,2S)-2-hydroxy-1,2-diphenyl-ethyl)-2,2-dimethyl-malonamide

: (4R,4'R,5S,5'S)-2,2'-(propane-2,2-diyl)bis(4,5-diphenyl-4,5-dihydrooxazole)

Guidance literature:: With hexaammonium heptamolybdate tetrahydrate; In 5,5-dimethyl-1,3-cyclohexadiene; for 24h; Dean-Stark; Reflux;
DOI:10.1021/ja3083494

Reference yield:

: 183866-68-4
N,N'-Bis-((1R,2S)-2-hydroxy-1,2-diphenyl-ethyl)-2,2-dimethyl-malonamide

: 157904-67-1,183072-30-2
2,2-bis<2-<4(R),5(R)-diphenyl-1,3-oxazolinyl>>propane

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

2: aq. NaOH / ethanol / 3 h / Heating

With sodium hydroxide; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/0040-4020(96)00817-4