2,6-difluoro-4-[(carboxymethoxyimino)methyl]phenylboronic acid pinacol ester

Base Information

Chemical Name:2,6-difluoro-4-[(carboxymethoxyimino)methyl]phenylboronic acid pinacol ester
CAS No.:1350626-30-0
Molecular Formula:C₁₅H₁₈BF₂NO₅
Molecular Weight:341.119
Hs Code.:

Synonyms:2,6-difluoro-4-[(carboxymethoxyimino)methyl]phenylboronic acid pinacol ester

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Chemical Property of 2,6-difluoro-4-[(carboxymethoxyimino)methyl]phenylboronic acid pinacol ester

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Technology Process of 2,6-difluoro-4-[(carboxymethoxyimino)methyl]phenylboronic acid pinacol ester

There total 1 articles about 2,6-difluoro-4-[(carboxymethoxyimino)methyl]phenylboronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 2-(aminooxy)acetic acid hemihydrochloride

: 870717-92-3
3,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde

: 1350626-30-0
2,6-difluoro-4-[(carboxymethoxyimino)methyl]phenylboronic acid pinacol ester

Guidance literature:: With Huenig's base; In acetonitrile; under Ar; mixt. of NH2OCH2CO2H*0.5HCl, B compd. and Huenig's base in anhyd. MeCN contg. molecular sieves (3?) stirred at room temp. for 2 h; solvent evapd.; dissolved in ethyl acetate; washed with H2O; dried (MgSO4); filtered; evapd.; solid recrystd. from mixt. of hot petroleum ether and a few drops of ethyl acetate;
DOI:10.1039/c1nj20417c

Reference yield: 100.0%

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 1350626-30-0
2,6-difluoro-4-[(carboxymethoxyimino)methyl]phenylboronic acid pinacol ester

: 1350626-31-1
2,6-difluoro-4-{[2-oxo-2-(pentafluorophenoxy)ethoxyimino]methyl}-phenylboronic acid pinacol ester

Guidance literature:: With EDC hydrochloride; In chloroform; under Ar; EDC hydrochloride and C6F5OH added to soln. of B compd. in CHCl3; stirred at room temp. for 15 h; solvent evapd.; dissolved in ethyl acetate-H2O; org. layer sepd.; dried (MgSO4); filtered; evapd.;
DOI:10.1039/c1nj20417c

Reference yield:

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 1350626-30-0
2,6-difluoro-4-[(carboxymethoxyimino)methyl]phenylboronic acid pinacol ester

: 1350898-79-1
potassium 2,6-difluoro-4-{[2-oxo-2-(pentafluorophenoxy)ethoxyimino]-methyl}phenyltrifluoroborate

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 15 h / 20 °C / Inert atmosphere

2: potassium hydrogen difluoride / methanol; water / 2 h / 20 °C

With potassium hydrogen difluoride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; chloroform; water;
DOI:10.1039/c1nj20417c