3-[(tert-butyloxycarbonyl)aminomethyl]-5-nitrobenzoic acid methyl ester

Base Information

Chemical Name:3-[(tert-butyloxycarbonyl)aminomethyl]-5-nitrobenzoic acid methyl ester
CAS No.:913077-69-7
Molecular Formula:C₁₄H₁₈N₂O₆
Molecular Weight:310.307
Hs Code.:

Synonyms:3-[(tert-butyloxycarbonyl)aminomethyl]-5-nitrobenzoic acid methyl ester

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Chemical Property of 3-[(tert-butyloxycarbonyl)aminomethyl]-5-nitrobenzoic acid methyl ester

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Technology Process of 3-[(tert-butyloxycarbonyl)aminomethyl]-5-nitrobenzoic acid methyl ester

There total 5 articles about 3-[(tert-butyloxycarbonyl)aminomethyl]-5-nitrobenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 209604-82-0
3-aminomethyl-5-nitrobenzoic acid methyl ester

: 913077-69-7
3-[(tert-butyloxycarbonyl)aminomethyl]-5-nitrobenzoic acid methyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃; for 12h;
DOI:10.1016/j.bmc.2006.05.006

Reference yield:

: 167215-64-7
3-azidomethyl-5-nitrobenzoic acid methyl ester

: 913077-69-7
3-[(tert-butyloxycarbonyl)aminomethyl]-5-nitrobenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / triethylamine; 1,3-propanedithiol / methanol / 12 h / 20 °C

2: 100 percent / triethylamine / tetrahydrofuran / 12 h / 0 °C

With 1.3-propanedithiol; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2006.05.006

Reference yield:

: 13290-96-5
dimethyl 5-nitroisophthalate

: 913077-69-7
3-[(tert-butyloxycarbonyl)aminomethyl]-5-nitrobenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 50 percent / diisobutylaluminum hydride / tetrahydrofuran; toluene / -78 - 20 °C

2: 95 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

3: 100 percent / sodium azide / dimethylformamide / 2 h / 50 °C

4: 85 percent / triethylamine; 1,3-propanedithiol / methanol / 12 h / 20 °C

5: 100 percent / triethylamine / tetrahydrofuran / 12 h / 0 °C

With 1.3-propanedithiol; sodium azide; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2006.05.006