2-[2-fluoro-4-(methylsulfonyl)phenyl]-5-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]benzo[d]oxazole

Base Information

Chemical Name:2-[2-fluoro-4-(methylsulfonyl)phenyl]-5-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]benzo[d]oxazole
CAS No.:1415992-12-9
Molecular Formula:C₂₄H₂₅FN₄O₄S
Molecular Weight:484.551
Hs Code.:

Synonyms:2-[2-fluoro-4-(methylsulfonyl)phenyl]-5-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]benzo[d]oxazole

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Chemical Property of 2-[2-fluoro-4-(methylsulfonyl)phenyl]-5-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]benzo[d]oxazole

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Technology Process of 2-[2-fluoro-4-(methylsulfonyl)phenyl]-5-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]benzo[d]oxazole

There total 3 articles about 2-[2-fluoro-4-(methylsulfonyl)phenyl]-5-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]benzo[d]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-isopropyl-5-(piperidin-4-yl)-1,2,4-oxadiazole hydrochloride salt

: 1415992-36-7
5-bromo-2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazole

: 1415992-12-9
2-[2-fluoro-4-(methylsulfonyl)phenyl]-5-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]benzo[d]oxazole

Guidance literature:: With potassium carbonate; acetylacetone; copper(l) chloride; In 1-methyl-pyrrolidin-2-one; at 130 ℃; for 16h; Inert atmosphere;

Reference yield:

: 142994-04-5
2-fluoro-4-(methylsulphonyl)benzoic acid

: 1415992-12-9
2-[2-fluoro-4-(methylsulfonyl)phenyl]-5-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]benzo[d]oxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: polyposphoric acid / 3.5 h / 195 °C

1.2: pH 9

2.1: potassium carbonate / copper(l) chloride; acetylacetone / 1-methyl-pyrrolidin-2-one / 16 h / 130 °C / Inert atmosphere

With potassium carbonate; acetylacetone; copper(l) chloride; In 1-methyl-pyrrolidin-2-one;

Reference yield:

: 40925-68-6
2-amino-4-bromo-phenol

: 1415992-12-9
2-[2-fluoro-4-(methylsulfonyl)phenyl]-5-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]benzo[d]oxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: polyposphoric acid / 3.5 h / 195 °C

1.2: pH 9

2.1: potassium carbonate / copper(l) chloride; acetylacetone / 1-methyl-pyrrolidin-2-one / 16 h / 130 °C / Inert atmosphere

With potassium carbonate; acetylacetone; copper(l) chloride; In 1-methyl-pyrrolidin-2-one;