1-(3-methylthiophenyl)-2-(2-methylthiopyrimidin-4-yl)-ethanone

Base Information

• Chemical Name: 1-(3-methylthiophenyl)-2-(2-methylthiopyrimidin-4-yl)-ethanone
• CAS No.: 616196-46-4
• Molecular Formula: C₁₄H₁₄N₂OS₂
• Molecular Weight: 290.41
• Mol file: 616196-46-4.mol

Synonyms:1-(3-methylthiophenyl)-2-(2-methylthiopyrimidin-4-yl)-ethanone

Chemical Property of 1-(3-methylthiophenyl)-2-(2-methylthiopyrimidin-4-yl)-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-(3-methylthiophenyl)-2-(2-methylthiopyrimidin-4-yl)-ethanone

There total 1 articles about 1-(3-methylthiophenyl)-2-(2-methylthiopyrimidin-4-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-methylthio-4-methylpyrimidine (14001-63-9) + ethyl 3-methylthiobenzoate (1442-02-0) → 1-(3-methylthiophenyl)-2-(2-methylthiopyrimidin-4-yl)-ethanone (616196-46-4)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2018.08.028

Reference yield: 25.0%

tert-butyl 4-carbamothioylpiperidine-1-carboxylate (214834-18-1) + 1-(3-methylthiophenyl)-2-(2-methylthiopyrimidin-4-yl)-ethanone (616196-46-4) → C25H30N4O2S3

Guidance literature:

1-(3-methylthiophenyl)-2-(2-methylthiopyrimidin-4-yl)-ethanone; With chloro-trimethyl-silane; tetrabutylammomium bromide; In tetrahydrofuran; dimethyl sulfoxide; at 0 - 20 ℃;

tert-butyl 4-carbamothioylpiperidine-1-carboxylate; In ethanol; Reflux;

DOI:10.1016/j.bmcl.2018.08.028

Reference yield:

1-(3-methylthiophenyl)-2-(2-methylthiopyrimidin-4-yl)-ethanone (616196-46-4) → C23H27N5O2S2

Guidance literature:

Multi-step reaction with 3 steps

1.1: chloro-trimethyl-silane; tetrabutylammomium bromide / tetrahydrofuran; dimethyl sulfoxide / 0 - 20 °C

1.2: Reflux

2.1: hydrogenchloride / 1,4-dioxane

3.1: acetic acid; dihydrogen peroxide; sodium tungstate (VI) dihydrate

3.2: 70 °C

With hydrogenchloride; chloro-trimethyl-silane; sodium tungstate (VI) dihydrate; tetrabutylammomium bromide; dihydrogen peroxide; acetic acid; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2018.08.028

upstream raw materials:

2-methylthio-4-methylpyrimidine

ethyl 3-methylthiobenzoate