2-(methylsulfonyl)ethyl 6'-bromo-1',2'-dihydro-5-hydroxy-5-methyl-3-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2',4'-dioxospiro<2-cyclopentene-1,3'-<3H>indole>-2-carboxylate

Base Information

• Chemical Name: 2-(methylsulfonyl)ethyl 6'-bromo-1',2'-dihydro-5-hydroxy-5-methyl-3-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2',4'-dioxospiro<2-cyclopentene-1,3'-<3H>indole>-2-carboxylate
• CAS No.: 123973-61-5
• Molecular Formula: C₃₆H₃₂BrN₅O₁₁S
• Molecular Weight: 822.647
• Mol file: 123973-61-5.mol

Synonyms:2-(methylsulfonyl)ethyl 6'-bromo-1',2'-dihydro-5-hydroxy-5-methyl-3-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2',4'-dioxospiro<2-cyclopentene-1,3'-<3H>indole>-2-carboxylate

Chemical Property of 2-(methylsulfonyl)ethyl 6'-bromo-1',2'-dihydro-5-hydroxy-5-methyl-3-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2',4'-dioxospiro<2-cyclopentene-1,3'-<3H>indole>-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(methylsulfonyl)ethyl 6'-bromo-1',2'-dihydro-5-hydroxy-5-methyl-3-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2',4'-dioxospiro<2-cyclopentene-1,3'-<3H>indole>-2-carboxylate

There total 23 articles about 2-(methylsulfonyl)ethyl 6'-bromo-1',2'-dihydro-5-hydroxy-5-methyl-3-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2',4'-dioxospiro<2-cyclopentene-1,3'-<3H>indole>-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-(methylsulfonyl)ethyl 6'-bromo-1',2'-dihydro-4-hydroxy-5-methyl-3-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2'-oxospiro<2-cyclopentene-1,3'-<3H>indole>-2-carboxylate (124059-45-6,143167-76-4,143167-84-4) → 2-(methylsulfonyl)ethyl 6'-bromo-1',2'-dihydro-5-hydroxy-5-methyl-3-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2',4'-dioxospiro<2-cyclopentene-1,3'-<3H>indole>-2-carboxylate (123973-61-5)

Guidance literature:

With benzeneseleninic anhydride; In 1,4-dioxane; at 80 ℃; for 2h;

DOI:10.1248/cpb.40.1110

Reference yield: 73.0%

2-(methylsulfonyl)ethyl 6'-bromo-1',2'-dihydro-3,5-dihydroxy-5-methyl-3-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2',4-dioxospiroindole>-2-carboxylate (109681-04-1) → 2-(methylsulfonyl)ethyl 6'-bromo-1',2'-dihydro-5-hydroxy-5-methyl-3-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2',4'-dioxospiro<2-cyclopentene-1,3'-<3H>indole>-2-carboxylate (123973-61-5)

Guidance literature:

With thionyl chloride; In pyridine; dichloromethane; at -15 ℃; for 0.166667h;

DOI:10.1016/S0040-4020(01)86990-8

Reference yield:

2-(methylsulfonyl)ethyl 6-bromo-2,3-dihydro-α-<1-hydroxy-1-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2-butynyl>-2-oxo-1H-indole-3-acetate (158320-68-4) → 2-(methylsulfonyl)ethyl 6'-bromo-1',2'-dihydro-5-hydroxy-5-methyl-3-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2',4'-dioxospiro<2-cyclopentene-1,3'-<3H>indole>-2-carboxylate (123973-61-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / pyridine / 0.17 h / -18 °C

2: 1.) OsO₄, 2.) NaHSO₃ / 1.) THF, ether, pyridine, 0 deg C, 2.) pyridine, H₂O, 1 h, room temp.

3: 73 percent / SOCl₂ / CH₂Cl₂; pyridine / 0.17 h / -15 °C

With pyridine; osmium(VIII) oxide; thionyl chloride; sodium hydrogensulfite; In pyridine; dichloromethane;

DOI:10.1016/S0040-4020(01)86990-8

upstream raw materials:

2-(methylsulfonyl)ethyl 6'-bromo-1',2'-dihydro-3,5-dihydroxy-5-methyl-3-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2',4-dioxospiroindole>-2-carboxylate

2-(methylsulfonyl)ethyl 6'-bromo-1',2'-dihydro-4-hydroxy-5-methyl-3-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2'-oxospiro<2-cyclopentene-1,3'-<3H>indole>-2-carboxylate

3-[(2,6-Bis-benzyloxy-5-nitro-pyrimidin-4-ylamino)-methyl]-2-(6-bromo-2-oxo-2,3-dihydro-1H-indol-3-yl)-3-hydroxy-hex-4-ynoic acid 2-methylsulfanyl-ethyl ester

2-(methylsulfonyl)ethyl 6-bromo-2,3-dihydro-α-<1-hydroxy-1-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2-butynyl>-2-oxo-1H-indole-3-acetate

Downstream raw materials:

2-(methylsulfonyl)ethyl 6'-bromo-1',2',8,8a,9,10-hexahydro-6-hydroxy-6-methyl-2'-oxo-2,4-bis(phenylmethoxy)-spiropyrimido<4,5-b><1,4>diazepine-7(6H),3'-<3H>indole>-8-carboxylate

1'-acetyl-6-(acetyloxy)-6'-bromo-1',2',8,8a,9,10-hexahydro-6-methyl-2'-oxo-2,4-bis(phenylmethoxy)spiropyrimido<4,5-b><1,4>diazepine-7(6H),3'-<3H>indole>-8-carboxylic acid

2-(methylsulfonyl)ethyl 1'-acetyl-6-(acetyloxy)-6'-bromo-1',2',8,8a,9,10-hexahydro-6-methyl-2'-oxo-2,4-bis(phenylmethoxy)spiropyrimido<4,5-b><1,4>diazepine-7(6H),3'-<3H>indole>-8-carboxylate