(Rp)-P-(2-iodophenyl)-P-phenyl-N-[(R)-1-phenylethyl]phosphinothioic amide

Base Information

Chemical Name:(Rp)-P-(2-iodophenyl)-P-phenyl-N-[(R)-1-phenylethyl]phosphinothioic amide
CAS No.:1431544-83-0
Molecular Formula:C₂₀H₁₉INPS
Molecular Weight:463.322
Hs Code.:

Synonyms:(Rp)-P-(2-iodophenyl)-P-phenyl-N-[(R)-1-phenylethyl]phosphinothioic amide

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Chemical Property of (Rp)-P-(2-iodophenyl)-P-phenyl-N-[(R)-1-phenylethyl]phosphinothioic amide

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Technology Process of (Rp)-P-(2-iodophenyl)-P-phenyl-N-[(R)-1-phenylethyl]phosphinothioic amide

There total 5 articles about (Rp)-P-(2-iodophenyl)-P-phenyl-N-[(R)-1-phenylethyl]phosphinothioic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: methyl ((Sp)-(2-iodophenyl)(phenyl){[(1R)-1-phenylethyl]amino}phosphoranylidene)carbamate

: 1431544-83-0
(Rp)-P-(2-iodophenyl)-P-phenyl-N-[(R)-1-phenylethyl]phosphinothioic amide

Guidance literature:: With phenyl isothiocyanate; In neat (no solvent); at 120 ℃; for 24h; Inert atmosphere; Schlenk technique;
DOI:10.1021/ol400971q

Reference yield:

: methyl (diphenyl{[(R)-1-phenylethyl]amino}phosphoranylidene)carbamate

: 1431544-83-0
(Rp)-P-(2-iodophenyl)-P-phenyl-N-[(R)-1-phenylethyl]phosphinothioic amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / tetrahydrofuran; cyclohexane / 15 h / -90 °C / Inert atmosphere; Schlenk technique

1.2: 1.5 h / Inert atmosphere; Schlenk technique

1.3: Inert atmosphere; Schlenk technique

2.1: phenyl isothiocyanate / neat (no solvent) / 24 h / 120 °C / Inert atmosphere; Schlenk technique

With tert.-butyl lithium; phenyl isothiocyanate; In tetrahydrofuran; cyclohexane; 2.1: |Aza-Wittig Reaction;
DOI:10.1021/ol400971q

Reference yield:

: 1079-66-9,74391-44-9
chloro-diphenylphosphine

: 1431544-83-0
(Rp)-P-(2-iodophenyl)-P-phenyl-N-[(R)-1-phenylethyl]phosphinothioic amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 0 - 20 °C / Inert atmosphere; Schlenk technique

2.1: toluene / 0 °C / Inert atmosphere; Schlenk technique

3.1: tert.-butyl lithium / tetrahydrofuran; cyclohexane / 15 h / -90 °C / Inert atmosphere; Schlenk technique

3.2: 1.5 h / Inert atmosphere; Schlenk technique

3.3: Inert atmosphere; Schlenk technique

4.1: phenyl isothiocyanate / neat (no solvent) / 24 h / 120 °C / Inert atmosphere; Schlenk technique

With tert.-butyl lithium; phenyl isothiocyanate; In tetrahydrofuran; cyclohexane; toluene; 4.1: |Aza-Wittig Reaction;
DOI:10.1021/ol400971q