Technology Process of ethyl 3-cyano-4-(1-naphthyl)benzoate
There total 8 articles about ethyl 3-cyano-4-(1-naphthyl)benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); potassium fluoride dihydrate;
In
1,2-dimethoxyethane; water;
at 80 ℃;
Inert atmosphere;
DOI:10.1016/j.bmcl.2010.12.110
- Guidance literature:
-
Multi-step reaction with 5 steps
1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux
2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
3: palladium 10% on activated carbon; hydrogen / ethanol / 15 h / 2585.81 Torr
4: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere
5: tetrakis(triphenylphosphine) palladium(0); potassium fluoride dihydrate / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere
With
pyridine; tetrakis(triphenylphosphine) palladium(0); thionyl chloride; potassium fluoride dihydrate; palladium 10% on activated carbon; hydrogen; triethylamine; N,N-dimethyl-formamide;
In
1,2-dimethoxyethane; ethanol; dichloromethane; water;
5: Suzuki coupling;
DOI:10.1016/j.bmcl.2010.12.110
- Guidance literature:
-
Multi-step reaction with 7 steps
1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
2: water; sodium hydroxide / ethanol / 3 h / 50 °C
3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux
4: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
5: palladium 10% on activated carbon; hydrogen / ethanol / 15 h / 2585.81 Torr
6: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere
7: tetrakis(triphenylphosphine) palladium(0); potassium fluoride dihydrate / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere
With
pyridine; tetrakis(triphenylphosphine) palladium(0); thionyl chloride; potassium fluoride dihydrate; palladium 10% on activated carbon; water; hydrogen; triethylamine; N,N-dimethyl-formamide; sodium hydroxide;
In
1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
7: Suzuki coupling;
DOI:10.1016/j.bmcl.2010.12.110
