(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(3-(5-methoxypyridin-3-yl)phenyl)-5-methylbenzo[d]thiazol-6-yl)acetic acid

Base Information

• Chemical Name: (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(3-(5-methoxypyridin-3-yl)phenyl)-5-methylbenzo[d]thiazol-6-yl)acetic acid
• CAS No.: 1471249-85-0
• Molecular Formula: C₃₂H₂₉ClN₂O₄S
• Molecular Weight: 573.112
• Mol file: 1471249-85-0.mol

Synonyms:(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(3-(5-methoxypyridin-3-yl)phenyl)-5-methylbenzo[d]thiazol-6-yl)acetic acid

Chemical Property of (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(3-(5-methoxypyridin-3-yl)phenyl)-5-methylbenzo[d]thiazol-6-yl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(3-(5-methoxypyridin-3-yl)phenyl)-5-methylbenzo[d]thiazol-6-yl)acetic acid

There total 14 articles about (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(3-(5-methoxypyridin-3-yl)phenyl)-5-methylbenzo[d]thiazol-6-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(3-(5-methoxypyridin-3-yl)phenyl)-5-methylbenzo[d]thiazol-6-yl)ethanol (1471256-47-9) → (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(3-(5-methoxypyridin-3-yl)phenyl)-5-methylbenzo[d]thiazol-6-yl)acetic acid (1471249-85-0)

Guidance literature:

With chromium(VI) oxide; periodic acid; In water; acetonitrile; at 0 ℃; for 0.5h;

Reference yield:

2-methyl-4-nitrophenol (99-53-6) → (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(3-(5-methoxypyridin-3-yl)phenyl)-5-methylbenzo[d]thiazol-6-yl)acetic acid (1471249-85-0)

Guidance literature:

Multi-step reaction with 14 steps

1.1: bromine; acetic acid / 4 h / 20 °C

2.1: triethylamine / dichloromethane / 0.33 h / -70 °C

3.1: lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

3.2: 0.17 h / 70 °C

4.1: methanesulfonamide; hydroquinine 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 72 h / 0 °C

5.1: pyridine / dichloromethane / 5 h / 0 - 20 °C

6.1: perchloric acid / 1.5 h / 0 - 20 °C

7.1: platinum on activated charcoal; hydrogen / ethanol / 3 h / 20 °C

8.1: acetic acid / 0.5 h / 20 °C

8.2: 2 h / 20 °C

9.1: copper dichloride; tert.-butylnitrite / acetonitrile / 5 h / 20 °C

10.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / 95 °C / Sealed tube

11.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 120 °C / Sealed tube

12.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 1 h / 20 °C

12.2: 1 h / 0 °C

13.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 120 °C / Sealed tube

13.2: 3 h / 45 °C

14.1: periodic acid; chromium(VI) oxide / acetonitrile; water / 0.5 h / 0 °C

With pyridine; chromium(VI) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; perchloric acid; methanesulfonamide; hydroquinine 1,4-phthalazinediyl diether; palladium 10% on activated carbon; platinum on activated charcoal; hydrogen; bromine; potassium carbonate; acetic acid; periodic acid; triethylamine; lithium chloride; copper dichloride; In 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

2-bromo-6-methyl-4-nitrophenol (4186-49-6) → (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(3-(5-methoxypyridin-3-yl)phenyl)-5-methylbenzo[d]thiazol-6-yl)acetic acid (1471249-85-0)

Guidance literature:

Multi-step reaction with 13 steps

1.1: triethylamine / dichloromethane / 0.33 h / -70 °C

2.1: lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

2.2: 0.17 h / 70 °C

3.1: methanesulfonamide; hydroquinine 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 72 h / 0 °C

4.1: pyridine / dichloromethane / 5 h / 0 - 20 °C

5.1: perchloric acid / 1.5 h / 0 - 20 °C

6.1: platinum on activated charcoal; hydrogen / ethanol / 3 h / 20 °C

7.1: acetic acid / 0.5 h / 20 °C

7.2: 2 h / 20 °C

8.1: copper dichloride; tert.-butylnitrite / acetonitrile / 5 h / 20 °C

9.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / 95 °C / Sealed tube

10.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 120 °C / Sealed tube

11.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 1 h / 20 °C

11.2: 1 h / 0 °C

12.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 120 °C / Sealed tube

12.2: 3 h / 45 °C

13.1: periodic acid; chromium(VI) oxide / acetonitrile; water / 0.5 h / 0 °C

With pyridine; chromium(VI) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; perchloric acid; methanesulfonamide; hydroquinine 1,4-phthalazinediyl diether; palladium 10% on activated carbon; platinum on activated charcoal; hydrogen; potassium carbonate; acetic acid; periodic acid; triethylamine; lithium chloride; copper dichloride; In 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

upstream raw materials:

2-bromo-6-methyl-4-nitrophenol

2-methyl-4-nitrophenol

2-bromo-6-methyl-4-nitrophenyl trifluoromethanesulfonate

1-bromo-3-methyl-5-nitro-2-vinylbenzene