N-(3-fluoro-4-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Base Information

Chemical Name:N-(3-fluoro-4-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
CAS No.:1262215-41-7
Molecular Formula:C₂₉H₃₀FN₇O
Molecular Weight:511.602
Hs Code.:

Synonyms:N-(3-fluoro-4-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

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Chemical Property of N-(3-fluoro-4-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

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Technology Process of N-(3-fluoro-4-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

There total 15 articles about N-(3-fluoro-4-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1262215-65-5
5-fluoro-6-methyl-N₁-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

: 106261-48-7
4-(4-methylpiperazin-1-ylmethyl)benzoic acid

: 1262215-41-7
N-(3-fluoro-4-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 36h; Inert atmosphere;

Reference yield:

: 1692-25-7
3-pyridylboronic acid

: 1262215-41-7
N-(3-fluoro-4-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 16 h / Heating; Reflux; Inert atmosphere

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾; XPhos / 1,4-dioxane / 18 h / Heating; Reflux; Inert atmosphere

3.1: hydrogen bromide; acetic acid / 12 h / 80 °C

3.2: pH 8

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 36 h / 20 °C / Inert atmosphere

With hydrogen bromide; sodium carbonate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 49592-71-4
methyl 4-methyl-3,5-dinitrobenzoate

: 1262215-41-7
N-(3-fluoro-4-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrazine / methanol / 24 h / 20 °C

2.1: sodium nitrite; acetic acid / water; methanol / 0 °C

2.2: 24 h / Heating; Reflux

3.1: sodiumsulfide nonahydrate / ethanol; water / 18 h / 20 °C

4.1: pyridine; sodium nitrite; hydrogen fluoride / water / 0 - 80 °C / Ice/salt bath; Sealed tube

5.1: water; iron / 2 h / 100 °C

6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾; XPhos / 1,4-dioxane / 18 h / Heating; Reflux; Inert atmosphere

7.1: hydrogen bromide; acetic acid / 12 h / 80 °C

7.2: pH 8

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 36 h / 20 °C / Inert atmosphere

With pyridine; sodiumsulfide nonahydrate; hydrogen fluoride; water; hydrogen bromide; iron; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; hydrazine; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; XPhos; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;