1,3,7,7-tetramethyl-4-(4-nitrophenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione

Base Information

• Chemical Name: 1,3,7,7-tetramethyl-4-(4-nitrophenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione
• CAS No.: 1555675-53-0
• Molecular Formula: C₁₈H₂₁N₃O₄
• Molecular Weight: 343.382

Synonyms:1,3,7,7-tetramethyl-4-(4-nitrophenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione

Chemical Property of 1,3,7,7-tetramethyl-4-(4-nitrophenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione

Chemical Property:

Purity/Quality:

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Technology Process of 1,3,7,7-tetramethyl-4-(4-nitrophenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione

There total 1 articles about 1,3,7,7-tetramethyl-4-(4-nitrophenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N,N'-Dimethylurea (96-31-1) + 4-nitrobenzaldehdye (555-16-8) + dimedone (126-81-8) → 1,3,7,7-tetramethyl-4-(4-nitrophenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione (1555675-53-0)

Guidance literature:

With alumina sulphuric acid (ASA); In ethanol; at 90 ℃; for 1h;

DOI:10.3109/14756366.2012.746972

Reference yield: 75.0%

1,3,7,7-tetramethyl-4-(4-nitrophenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione (1555675-53-0) → 4-(4-aminophenyl)-1,3,7,7-tetramethyl-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione (1555675-56-3)

Guidance literature:

With tin(II) chloride dihdyrate; In ethanol; for 4h; Reflux;

DOI:10.3109/14756366.2012.746972

Reference yield:

1,3,7,7-tetramethyl-4-(4-nitrophenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione (1555675-53-0) → 1-(3-fluorophenyl)-3-(4-(1,3,7,7-tetramethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)phenyl)thiourea (1555675-79-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tin(II) chloride dihdyrate / ethanol / 4 h / Reflux

2: toluene / 20 h / 60 °C

With tin(II) chloride dihdyrate; In ethanol; toluene;

DOI:10.3109/14756366.2012.746972

upstream raw materials:

N,N'-Dimethylurea

4-nitrobenzaldehdye

dimedone

Downstream raw materials:

1-(4-nitrophenyl)-3-(4-(1,3,7,7-tetramethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)phenyl)thiourea

1-(4-(1,3,7,7-tetramethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)thiourea

1-(2,4-dichlorophenyl)-3-(4-(1,3,7,7-tetramethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)phenyl)thiourea

1-(3-fluorophenyl)-3-(4-(1,3,7,7-tetramethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)phenyl)thiourea

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