1-(2-chlorophenyl)-3-(1H-indol-1-yl)acetone oxime

Base Information

• Chemical Name: 1-(2-chlorophenyl)-3-(1H-indol-1-yl)acetone oxime
• CAS No.: 1335284-78-0
• Molecular Formula: C₁₇H₁₅ClN₂O
• Molecular Weight: 298.772
• Mol file: 1335284-78-0.mol

Synonyms:1-(2-chlorophenyl)-3-(1H-indol-1-yl)acetone oxime

Chemical Property of 1-(2-chlorophenyl)-3-(1H-indol-1-yl)acetone oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-chlorophenyl)-3-(1H-indol-1-yl)acetone oxime

There total 8 articles about 1-(2-chlorophenyl)-3-(1H-indol-1-yl)acetone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-(2-chlorophenyl)-3-(1H-indol-1-yl)acetone (1335284-76-8) → 1-(2-chlorophenyl)-3-(1H-indol-1-yl)acetone oxime (1335284-78-0)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; for 2h; Reflux;

DOI:10.1016/j.tet.2011.07.074

Reference yield:

indole (120-72-9) → 1-(2-chlorophenyl)-3-(1H-indol-1-yl)acetone oxime (1335284-78-0)

Guidance literature:

Multi-step reaction with 7 steps

1: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 20 °C

2: lithium hydroxide / tetrahydrofuran; water / 8 h / 20 °C

3: 4-methyl-morpholine / tetrahydrofuran / 0.08 h / -10 °C

4: sodium azide / tetrahydrofuran; water / 0.5 h / -10 - 20 °C

5: toluene / 0.5 h / 65 °C

6: dmap; formic acid / dichloromethane / 2 h / 20 °C

7: hydroxylamine hydrochloride; sodium acetate / ethanol / 2 h / Reflux

With 4-methyl-morpholine; dmap; formic acid; sodium azide; hydroxylamine hydrochloride; tetrabutylammomium bromide; sodium acetate; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; 5: Curtius rearrangement;

DOI:10.1016/j.tet.2011.07.074

Reference yield:

C18H13ClN4O → 1-(2-chlorophenyl)-3-(1H-indol-1-yl)acetone oxime (1335284-78-0)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 0.5 h / 65 °C

2: dmap; formic acid / dichloromethane / 2 h / 20 °C

3: hydroxylamine hydrochloride; sodium acetate / ethanol / 2 h / Reflux

With dmap; formic acid; hydroxylamine hydrochloride; sodium acetate; In ethanol; dichloromethane; toluene; 1: Curtius rearrangement;

DOI:10.1016/j.tet.2011.07.074

upstream raw materials:

indole

C₁₉H₁₆ClNO₂

(E)-3-(2-chlorophenyl)-2-(1H-indol-1-ylmethyl)prop-2-enoic acid

1-(2-chlorophenyl)-3-(1H-indol-1-yl)acetone