5'-O-(4,4'-dimethoxytrityl)-1-methyl-2'-O-[[(triisopropylsilyl)oxy]methyl]inosine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-1-methyl-2'-O-[[(triisopropylsilyl)oxy]methyl]inosine
CAS No.:661471-80-3
Molecular Formula:C₄₂H₅₄N₄O₈Si
Molecular Weight:770.998
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-1-methyl-2'-O-[[(triisopropylsilyl)oxy]methyl]inosine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-1-methyl-2'-O-[[(triisopropylsilyl)oxy]methyl]inosine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-1-methyl-2'-O-[[(triisopropylsilyl)oxy]methyl]inosine

There total 6 articles about 5'-O-(4,4'-dimethoxytrityl)-1-methyl-2'-O-[[(triisopropylsilyl)oxy]methyl]inosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 217300-17-9
chloromethoxy-triisopropyl-silane

: 236752-17-3
5'-O-(4,4'-dimethoxytrityl)-1-methylinosine

: 5'-O-(4,4'-dimethoxytrityl)-1-methyl-3'-O-[[(triisopropylsilyl)oxy]methyl]inosine

: 661471-80-3
5'-O-(4,4'-dimethoxytrityl)-1-methyl-2'-O-[[(triisopropylsilyl)oxy]methyl]inosine

Guidance literature:: 5'-O-(4,4'-dimethoxytrityl)-1-methylinosine; With di-tert-butyltin dichloride; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 70 ℃; for 0.25h;

chloromethoxy-triisopropyl-silane; In 1,2-dichloro-ethane; at 20 ℃; for 3h;
DOI:10.1007/s00706-003-0592-1

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 661471-80-3
5'-O-(4,4'-dimethoxytrityl)-1-methyl-2'-O-[[(triisopropylsilyl)oxy]methyl]inosine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 939 mg / pyridine / 2 h / 20 °C

2.1: K₂CO₃ / dimethylformamide / 1.5 h / -15 °C

2.2: 98 percent / dimethylformamide / 2 h / 20 °C

With pyridine; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1002/hlca.200590209

Reference yield:

: 9-((2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-triisopropylsilanyloxymethoxy-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one

: 661471-80-3
5'-O-(4,4'-dimethoxytrityl)-1-methyl-2'-O-[[(triisopropylsilyl)oxy]methyl]inosine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 939 mg / pyridine / 2 h / 20 °C

2.1: K₂CO₃ / dimethylformamide / 1.5 h / -15 °C

2.2: 98 percent / dimethylformamide / 2 h / 20 °C

With pyridine; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1002/hlca.200590209