[3(5S),4R,5S]-3-[5-t-butoxycarbonylamino-6-phenyl-E-3-hexenoyl]-4-methyl-5-phenyl-2-oxazolidinone

Base Information

Chemical Name:[3(5S),4R,5S]-3-[5-t-butoxycarbonylamino-6-phenyl-E-3-hexenoyl]-4-methyl-5-phenyl-2-oxazolidinone
CAS No.:870301-33-0
Molecular Formula:C₂₇H₃₂N₂O₅
Molecular Weight:464.561
Hs Code.:

Synonyms:[3(5S),4R,5S]-3-[5-t-butoxycarbonylamino-6-phenyl-E-3-hexenoyl]-4-methyl-5-phenyl-2-oxazolidinone

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Chemical Property of [3(5S),4R,5S]-3-[5-t-butoxycarbonylamino-6-phenyl-E-3-hexenoyl]-4-methyl-5-phenyl-2-oxazolidinone

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Technology Process of [3(5S),4R,5S]-3-[5-t-butoxycarbonylamino-6-phenyl-E-3-hexenoyl]-4-methyl-5-phenyl-2-oxazolidinone

There total 3 articles about [3(5S),4R,5S]-3-[5-t-butoxycarbonylamino-6-phenyl-E-3-hexenoyl]-4-methyl-5-phenyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₃₁NO₅

: 77943-39-6
4-methyl-5-phenyloxazolidin-2-one

: 870301-33-0
[3(5S),4R,5S]-3-[5-t-butoxycarbonylamino-6-phenyl-E-3-hexenoyl]-4-methyl-5-phenyl-2-oxazolidinone

Guidance literature:: 4-methyl-5-phenyloxazolidin-2-one; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.333333h;

C₂₂H₃₁NO₅; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1021/ja0551382

Reference yield:

: (S)-2-t-butoxycarbonylamino-1-phenyl-6-trimethylsilylhex-E/Z-3-en-5-yne

: 870301-33-0
[3(5S),4R,5S]-3-[5-t-butoxycarbonylamino-6-phenyl-E-3-hexenoyl]-4-methyl-5-phenyl-2-oxazolidinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: cyclohexene; BH₃

1.2: 82 percent / aq. H₂O₂

2.1: triethylamine / tetrahydrofuran / -78 - 0 °C

3.1: n-BuLi / tetrahydrofuran / 0.33 h / -78 °C

3.2: 3.8 g / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; borane; triethylamine; cyclohexene; In tetrahydrofuran;
DOI:10.1021/ja0551382

Reference yield:

: 82042-48-6
(S)-5-<(tert-Butoxycarbonyl)amino>-6-phenyl-(E)-3-hexenoic acid

: 870301-33-0
[3(5S),4R,5S]-3-[5-t-butoxycarbonylamino-6-phenyl-E-3-hexenoyl]-4-methyl-5-phenyl-2-oxazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / -78 - 0 °C

2.1: n-BuLi / tetrahydrofuran / 0.33 h / -78 °C

2.2: 3.8 g / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; triethylamine; In tetrahydrofuran;
DOI:10.1021/ja0551382