6-(3,4-dimethoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile

Base Information

• Chemical Name: 6-(3,4-dimethoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
• CAS No.: 78558-43-7
• Molecular Formula: C₁₄H₁₂N₂O₃
• Molecular Weight: 256.261
• Mol file: 78558-43-7.mol

Synonyms:6-(3,4-dimethoxyphenyl)-3-cyano-1,2-dihydro-2-oxopyridine

Chemical Property of 6-(3,4-dimethoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(3,4-dimethoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile

There total 3 articles about 6-(3,4-dimethoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3,4-dimethoxyphenyl)ethanone (1131-62-0) + cyanoacetic acid amide (107-91-5) → 6-(3,4-dimethoxyphenyl)-3-cyano-1,2-dihydro-2-oxopyridine (78558-43-7)

Guidance literature:

With sodium methylate; In ethanol; di-isopropyl ether; water; formic acid ethyl ester;

Reference yield:

cyanoacetic acid amide (107-91-5) + 1-(3,4-dimethoxyphenyl)-3-(dimethylamino)prop-2-en-1-one (127172-22-9) → 6-(3,4-dimethoxyphenyl)-3-cyano-1,2-dihydro-2-oxopyridine (78558-43-7)

Guidance literature:

With sodium methylate; In acetonitrile; at 80 ℃;

DOI:10.1016/S0960-894X(03)00645-0

Reference yield:

1-(3,4-dimethoxyphenyl)ethanone (1131-62-0) → 6-(3,4-dimethoxyphenyl)-3-cyano-1,2-dihydro-2-oxopyridine (78558-43-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 12 h / Heating

2: NaOMe / acetonitrile / 80 °C

With sodium methylate; In acetonitrile;

DOI:10.1016/S0960-894X(03)00645-0

upstream raw materials:

cyanoacetic acid amide

1-(3,4-dimethoxyphenyl)-3-(dimethylamino)prop-2-en-1-one

1-(3,4-dimethoxyphenyl)ethanone

Downstream raw materials:

2-chloro-6-(3,4-dimethoxyphenyl)nicotinonitrile