diethyl [(3S)-3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)-1,1-difluoro-4-hydroxybutyl]phosphonate

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Chemical Name:diethyl [(3S)-3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)-1,1-difluoro-4-hydroxybutyl]phosphonate
CAS No.:1404217-14-6
Molecular Formula:C₂₂H₂₉F₂N₄O₅P
Molecular Weight:498.467
Hs Code.:

Synonyms:diethyl [(3S)-3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)-1,1-difluoro-4-hydroxybutyl]phosphonate

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Chemical Property of diethyl [(3S)-3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)-1,1-difluoro-4-hydroxybutyl]phosphonate

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Technology Process of diethyl [(3S)-3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)-1,1-difluoro-4-hydroxybutyl]phosphonate

There total 2 articles about diethyl [(3S)-3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)-1,1-difluoro-4-hydroxybutyl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1166948-81-7
4-benzyloxy-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde

: 1404217-13-5
diethyl [(3S)-3-amino-1,1-difluoro-4-hydroxybutyl]phosphonate hydrochloride

: 1404217-14-6
diethyl [(3S)-3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)-1,1-difluoro-4-hydroxybutyl]phosphonate

Guidance literature:: With 2-picoline borane complex; triethylamine; In methanol; at 50 ℃; for 24h;

Reference yield:

: 162107-90-6
(S)-N-(tert-butyloxycarbonyl)-1,2-(N,O-isopropylidene)-3-<1',1'-difluoro(diethylphosphono)methyl>alaninol

: 1404217-14-6
diethyl [(3S)-3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)-1,1-difluoro-4-hydroxybutyl]phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: water; hydrogenchloride / ethanol / 1.5 h / 20 °C

2: 2-picoline borane complex; triethylamine / methanol / 24 h / 50 °C

With hydrogenchloride; 2-picoline borane complex; water; triethylamine; In methanol; ethanol;
DOI:10.1016/j.bmc.2013.02.016