(rac)-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-pyrimidin-2-amine

Base Information

Chemical Name:(rac)-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-pyrimidin-2-amine
CAS No.:1427314-17-7
Molecular Formula:C₁₉H₁₈F₂N₄O₂S
Molecular Weight:404.44
Hs Code.:

Synonyms:(rac)-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-pyrimidin-2-amine

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Chemical Property of (rac)-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-pyrimidin-2-amine

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Technology Process of (rac)-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-pyrimidin-2-amine

There total 10 articles about (rac)-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1427314-15-5
(rac)-ethyl[(3-{[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino}benzyl)(methyl)oxido-λ⁶-sulfanylidene]carbamate

: 1427314-17-7
(rac)-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-pyrimidin-2-amine

Guidance literature:: With sodium ethanolate; In ethanol; at 60 ℃; for 5h; Inert atmosphere;

Reference yield:

: 1414944-20-9
(rac)-ethyl [methyl(3-nitrobenzyl)oxido-λ⁶-sulfanylidene]carbamate

: 1427314-17-7
(rac)-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; titanium(III) chloride / tetrahydrofuran / 18 h / 20 °C

2: potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; XPhos / 1-methyl-pyrrolidin-2-one; toluene / 3 h / 130 °C / Inert atmosphere; Microwave irradiation

3: sodium ethanolate / ethanol / 5 h / 60 °C / Inert atmosphere

With hydrogenchloride; potassium phosphate; titanium(III) chloride; chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; sodium ethanolate; XPhos; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; toluene;

Reference yield:

: 1414944-22-1
(rac)-ethyl [(3-aminobenzyl)(methyl)oxido-λ⁶-sulfanylidene]carbamate

: 1427314-17-7
(rac)-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; XPhos / 1-methyl-pyrrolidin-2-one; toluene / 3 h / 130 °C / Inert atmosphere; Microwave irradiation

2: sodium ethanolate / ethanol / 5 h / 60 °C / Inert atmosphere

With potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; sodium ethanolate; XPhos; In 1-methyl-pyrrolidin-2-one; ethanol; toluene;