Technology Process of (R)-4-((1-cyclobutylethyl)amino)-2-(4-isopropylpyridin-2-yl)-7-methyl-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile
There total 11 articles about (R)-4-((1-cyclobutylethyl)amino)-2-(4-isopropylpyridin-2-yl)-7-methyl-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium diacetate; cesium fluoride; catacxium A; Trimethylacetic acid;
In
1,4-dioxane;
at 130 ℃;
for 72h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: caesium carbonate / N,N-dimethyl acetamide / 2 h / 20 °C
2.1: potassium fluoride / N,N-dimethyl acetamide / 0.08 h / 20 °C
2.2: 120 °C
3.1: bis(η3-allyl-μ-chloropalladium(II)) / N,N-dimethyl acetamide / 120 °C / Inert atmosphere
4.1: N-Bromosuccinimide / chloroform / 1 h / 20 - 45 °C / Inert atmosphere; Sealed tube
5.1: 1,1'-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride-chloroform adduct; potassium phosphate / 1,4-dioxane; water / 0.17 h / 120 °C / Inert atmosphere; Microwave irradiation
6.1: palladium diacetate; catacxium A; Trimethylacetic acid; cesium fluoride / 1,4-dioxane / 72 h / 130 °C / Inert atmosphere
With
potassium fluoride; potassium phosphate; N-Bromosuccinimide; 1,1'-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride-chloroform adduct; bis(η3-allyl-μ-chloropalladium(II)); palladium diacetate; caesium carbonate; cesium fluoride; catacxium A; Trimethylacetic acid;
In
1,4-dioxane; chloroform; N,N-dimethyl acetamide; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium fluoride / N,N-dimethyl acetamide / 0.08 h / 20 °C
1.2: 120 °C
2.1: bis(η3-allyl-μ-chloropalladium(II)) / N,N-dimethyl acetamide / 120 °C / Inert atmosphere
3.1: N-Bromosuccinimide / chloroform / 1 h / 20 - 45 °C / Inert atmosphere; Sealed tube
4.1: 1,1'-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride-chloroform adduct; potassium phosphate / 1,4-dioxane; water / 0.17 h / 120 °C / Inert atmosphere; Microwave irradiation
5.1: palladium diacetate; catacxium A; Trimethylacetic acid; cesium fluoride / 1,4-dioxane / 72 h / 130 °C / Inert atmosphere
With
potassium fluoride; potassium phosphate; N-Bromosuccinimide; 1,1'-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride-chloroform adduct; bis(η3-allyl-μ-chloropalladium(II)); palladium diacetate; cesium fluoride; catacxium A; Trimethylacetic acid;
In
1,4-dioxane; chloroform; N,N-dimethyl acetamide; water;