(R)-4-((1-cyclobutylethyl)amino)-2-(4-isopropylpyridin-2-yl)-7-methyl-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

Base Information

Chemical Name:(R)-4-((1-cyclobutylethyl)amino)-2-(4-isopropylpyridin-2-yl)-7-methyl-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile
CAS No.:1616436-50-0
Molecular Formula:C₃₀H₃₁F₃N₆
Molecular Weight:532.612
Hs Code.:

Synonyms:(R)-4-((1-cyclobutylethyl)amino)-2-(4-isopropylpyridin-2-yl)-7-methyl-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

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Chemical Property of (R)-4-((1-cyclobutylethyl)amino)-2-(4-isopropylpyridin-2-yl)-7-methyl-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

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Technology Process of (R)-4-((1-cyclobutylethyl)amino)-2-(4-isopropylpyridin-2-yl)-7-methyl-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

There total 11 articles about (R)-4-((1-cyclobutylethyl)amino)-2-(4-isopropylpyridin-2-yl)-7-methyl-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616434-21-9
(R)-4-((1-cyclobutylethyl)amino)-7-methyl-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

: 1086381-43-2
2-bromo-4-isopropylpyridine

: 1616436-50-0
(R)-4-((1-cyclobutylethyl)amino)-2-(4-isopropylpyridin-2-yl)-7-methyl-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

Guidance literature:: With palladium diacetate; cesium fluoride; catacxium A; Trimethylacetic acid; In 1,4-dioxane; at 130 ℃; for 72h; Inert atmosphere;

Reference yield:

: 402-49-3
4-bromomethyltrifluoromethylbenzene

: 1616436-50-0
(R)-4-((1-cyclobutylethyl)amino)-2-(4-isopropylpyridin-2-yl)-7-methyl-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl acetamide / 2 h / 20 °C

2.1: potassium fluoride / N,N-dimethyl acetamide / 0.08 h / 20 °C

2.2: 120 °C

3.1: bis(η3-allyl-μ-chloropalladium(II)) / N,N-dimethyl acetamide / 120 °C / Inert atmosphere

4.1: N-Bromosuccinimide / chloroform / 1 h / 20 - 45 °C / Inert atmosphere; Sealed tube

5.1: 1,1'-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride-chloroform adduct; potassium phosphate / 1,4-dioxane; water / 0.17 h / 120 °C / Inert atmosphere; Microwave irradiation

6.1: palladium diacetate; catacxium A; Trimethylacetic acid; cesium fluoride / 1,4-dioxane / 72 h / 130 °C / Inert atmosphere

With potassium fluoride; potassium phosphate; N-Bromosuccinimide; 1,1'-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride-chloroform adduct; bis(η3-allyl-μ-chloropalladium(II)); palladium diacetate; caesium carbonate; cesium fluoride; catacxium A; Trimethylacetic acid; In 1,4-dioxane; chloroform; N,N-dimethyl acetamide; water;

Reference yield:

: 1616434-17-3
4,6-dichloro-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine

: 1616436-50-0
(R)-4-((1-cyclobutylethyl)amino)-2-(4-isopropylpyridin-2-yl)-7-methyl-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium fluoride / N,N-dimethyl acetamide / 0.08 h / 20 °C

1.2: 120 °C

2.1: bis(η3-allyl-μ-chloropalladium(II)) / N,N-dimethyl acetamide / 120 °C / Inert atmosphere

3.1: N-Bromosuccinimide / chloroform / 1 h / 20 - 45 °C / Inert atmosphere; Sealed tube

4.1: 1,1'-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride-chloroform adduct; potassium phosphate / 1,4-dioxane; water / 0.17 h / 120 °C / Inert atmosphere; Microwave irradiation

5.1: palladium diacetate; catacxium A; Trimethylacetic acid; cesium fluoride / 1,4-dioxane / 72 h / 130 °C / Inert atmosphere

With potassium fluoride; potassium phosphate; N-Bromosuccinimide; 1,1'-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride-chloroform adduct; bis(η3-allyl-μ-chloropalladium(II)); palladium diacetate; cesium fluoride; catacxium A; Trimethylacetic acid; In 1,4-dioxane; chloroform; N,N-dimethyl acetamide; water;