3-(2-(4-chlorophenyl)vinylidene)-4-(prop-1-en-2-yl)-1-tosylpyrrolidine

Base Information

Chemical Name:3-(2-(4-chlorophenyl)vinylidene)-4-(prop-1-en-2-yl)-1-tosylpyrrolidine
CAS No.:1266550-27-9
Molecular Formula:C₂₂H₂₂ClNO₂S
Molecular Weight:399.941
Hs Code.:

Synonyms:3-(2-(4-chlorophenyl)vinylidene)-4-(prop-1-en-2-yl)-1-tosylpyrrolidine

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Chemical Property of 3-(2-(4-chlorophenyl)vinylidene)-4-(prop-1-en-2-yl)-1-tosylpyrrolidine

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Technology Process of 3-(2-(4-chlorophenyl)vinylidene)-4-(prop-1-en-2-yl)-1-tosylpyrrolidine

There total 3 articles about 3-(2-(4-chlorophenyl)vinylidene)-4-(prop-1-en-2-yl)-1-tosylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1174503-08-2
C₂₂H₂₄ClNO₃S

: 1266550-27-9
3-(2-(4-chlorophenyl)vinylidene)-4-(prop-1-en-2-yl)-1-tosylpyrrolidine

Guidance literature:: With trifluorormethanesulfonic acid; In dichloromethane; water; at 0 ℃; for 0.0833333h;
DOI:10.1002/chem.201002222

Reference yield: 55.0%

: 1363388-20-8
C₂₄H₂₆ClNO₅S

: 1266550-27-9
3-(2-(4-chlorophenyl)vinylidene)-4-(prop-1-en-2-yl)-1-tosylpyrrolidine

Guidance literature:: With trifuran-2-yl-phosphane; potassium acetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 85 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jo202590w

Reference yield:

: 132330-44-0
N-prenyl-N-propargyltosylamide

: 1266550-27-9
3-(2-(4-chlorophenyl)vinylidene)-4-(prop-1-en-2-yl)-1-tosylpyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethylmagnesium bromide / tetrahydrofuran / 1 h / 50 °C

1.2: 3 h / 20 °C

2.1: pyridine / dichloromethane / 2.5 h / 0 °C

3.1: trifuran-2-yl-phosphane; potassium acetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 85 °C / Inert atmosphere

With pyridine; trifuran-2-yl-phosphane; ethylmagnesium bromide; potassium acetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo202590w