Technology Process of 1-ethyl-5-hydroxy-4-(2-methoxy-3-methylsulfonyl-4-(trifluoromethyl)benzoyl)pyrazole
There total 8 articles about 1-ethyl-5-hydroxy-4-(2-methoxy-3-methylsulfonyl-4-(trifluoromethyl)benzoyl)pyrazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium cyanide; triethylamine; 2-hydroxy-2-methylpropanenitrile;
In
acetonitrile;
at 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 3 h / -78 - 20 °C
2.1: n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 - -65 °C / Inert atmosphere
2.2: -78 - 20 °C
3.1: sulfuric acid / Reflux
4.1: methanol / 6 h / Reflux
5.1: sodium hydroxide / water; methanol / 4 h / 20 °C
5.2: 20 °C / Cooling with ice
6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C
7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C
8.1: potassium cyanide; 2-hydroxy-2-methylpropanenitrile; triethylamine / acetonitrile / 16 h / 20 °C
With
potassium cyanide; n-butyllithium; sulfuric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; diisopropylamine; 2-hydroxy-2-methylpropanenitrile; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 - -65 °C / Inert atmosphere
1.2: -78 - 20 °C
2.1: sulfuric acid / Reflux
3.1: methanol / 6 h / Reflux
4.1: sodium hydroxide / water; methanol / 4 h / 20 °C
4.2: 20 °C / Cooling with ice
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C
6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C
7.1: potassium cyanide; 2-hydroxy-2-methylpropanenitrile; triethylamine / acetonitrile / 16 h / 20 °C
With
potassium cyanide; n-butyllithium; sulfuric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 2-hydroxy-2-methylpropanenitrile; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; acetonitrile;
