(2R,4R)-2-[4-(N-tert-butoxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine

Base Information

Chemical Name:(2R,4R)-2-[4-(N-tert-butoxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine
CAS No.:272786-44-4
Molecular Formula:C₂₈H₄₈N₂O₅Si
Molecular Weight:520.785
Hs Code.:

Synonyms:(2R,4R)-2-[4-(N-tert-butoxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine

Suppliers and Price of (2R,4R)-2-[4-(N-tert-butoxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,4R)-2-[4-(N-tert-butoxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4R)-2-[4-(N-tert-butoxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine

There total 4 articles about (2R,4R)-2-[4-(N-tert-butoxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1027089-21-9
4-(tert-butyl-dimethyl-silanyloxy)-2-(4-methylaminomethyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 272786-44-4
(2R,4R)-2-[4-(N-tert-butoxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine

Guidance literature:: With TEA; In 1,4-dioxane; water; at 10 - 15 ℃; for 0.5h;
DOI:10.1248/cpb.49.476

Reference yield:

: 228267-22-9
(2R,4R)-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxy-2-(4-formylphenyl)pyrrolidine

: 272786-44-4
(2R,4R)-2-[4-(N-tert-butoxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 91.1 percent / NaBH₄ / methanol / 0.5 h / 0 °C

2: TEA / CH₂Cl₂ / 0.25 h / -30 °C

3: methanol / 0.5 h / -10 °C

4: TEA / dioxane; H₂O / 0.5 h / 10 - 15 °C

With sodium tetrahydroborate; TEA; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1248/cpb.49.476

Reference yield:

: 228267-23-0
(2R,4R)-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxy-2-[4-(hydroxymethyl)phenyl]pyrrolidine

: 272786-44-4
(2R,4R)-2-[4-(N-tert-butoxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: TEA / CH₂Cl₂ / 0.25 h / -30 °C

2: methanol / 0.5 h / -10 °C

3: TEA / dioxane; H₂O / 0.5 h / 10 - 15 °C

With TEA; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1248/cpb.49.476