methyl 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxylate

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Chemical Name:methyl 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxylate
CAS No.:1403458-91-2
Molecular Formula:C₂₆H₂₆F₂N₂O₅
Molecular Weight:484.5
Hs Code.:

Synonyms:methyl 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxylate

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Chemical Property of methyl 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxylate

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Technology Process of methyl 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxylate

There total 14 articles about methyl 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 461-96-1
3,5-difluorobromobenzene

: 1403458-90-1
methyl 2-((R)-2-methylmorpholino)-4-oxo-8-(pyrrolidin-2-yl)-4H-chromene-6-carboxylate

: 1403458-91-2
methyl 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxylate

Guidance literature:: With caesium carbonate; palladium diacetate; In 1,4-dioxane; at 100 ℃; for 20h; Inert atmosphere;

Reference yield:

: 1403458-88-7
tert-butyl 2-(6-(methoxycarbonyl)-2-((R)-2-methylmorpholino)-4-oxo-4H-chromen-8-yl)pyrrolidine-1-carboxylate

: 1403458-91-2
methyl 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / dichloromethane; water / 16 h / 20 °C

2: caesium carbonate / palladium diacetate / 1,4-dioxane / 20 h / 100 °C / Inert atmosphere

With hydrogenchloride; caesium carbonate; palladium diacetate; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 29415-97-2
methyl 3-bromo-4-hydroxybenzoate

: 1403458-91-2
methyl 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1: triethylamine / palladium diacetate; 1,1'-bis(diphenylphosphino)ferrocene / ethanol / 70 °C / Inert atmosphere

2: bromine; pyridine / dichloromethane / 2 h / 0 - 20 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -50 - -5 °C / Inert atmosphere

4: potassium carbonate / acetone / 1 h / Reflux; Inert atmosphere

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C / Cooling with ice; Inert atmosphere

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 5 - 20 °C / Inert atmosphere

7: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.1 h / 80 °C / Inert atmosphere

8: hydrogen / 5% rhodium on activated aluminium oxide / methanol / 3 h / 65 °C / 3750.38 Torr

9: hydrogenchloride / dichloromethane; water / 16 h / 20 °C

10: caesium carbonate / palladium diacetate / 1,4-dioxane / 20 h / 100 °C / Inert atmosphere

With pyridine; hydrogenchloride; hydrogen; bromine; sodium carbonate; potassium carbonate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; bis-triphenylphosphine-palladium(II) chloride; 1,1'-bis(diphenylphosphino)ferrocene; 5% rhodium on activated aluminium oxide; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetone;