benzyl (3S,4R)-4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate

Base Information

Chemical Name:benzyl (3S,4R)-4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate
CAS No.:1007596-76-0
Molecular Formula:C₂₂H₂₄Cl₂N₆O₄
Molecular Weight:507.376
Hs Code.:

Synonyms:benzyl (3S,4R)-4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate

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Chemical Property of benzyl (3S,4R)-4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate

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Technology Process of benzyl (3S,4R)-4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate

There total 3 articles about benzyl (3S,4R)-4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1007596-67-9
benzyl (3S,4R)-3-azido-4-[(3,4-dichloro-5-methyl-1H-pyrrole-2-carbonyl)amino]piperidine-1-carboxylate

: 107-19-7
propargyl alcohol

: 1007596-76-0
benzyl (3S,4R)-4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate

Guidance literature:: With sodium L-ascorbate; copper(II) sulfate; In water; tert-butyl alcohol; at 20 ℃; for 18h;

Reference yield:

: 1007596-66-8
benzyl (3S,4R)-4-amino-3-azidopiperidine-1-carboxylate

: 1007596-76-0
benzyl (3S,4R)-4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h

2: sodium L-ascorbate / copper(II) sulfate / water; tert-butyl alcohol / 18 h / 20 °C

With sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; HATU; copper(II) sulfate; In water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1007596-65-7
benzyl (3S,4R)-3-azido-4-(benzhydrylideneamino)piperidine-1-carboxylate

: 1007596-76-0
benzyl (3S,4R)-4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: water; pyridinium p-toluenesulfonate / tetrahydrofuran / 12 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h

3: sodium L-ascorbate / copper(II) sulfate / water; tert-butyl alcohol / 18 h / 20 °C

With water; pyridinium p-toluenesulfonate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; HATU; copper(II) sulfate; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;