1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[(1S)-2-methoxy-1-phenylethylamino]ethanone

Base Information

• Chemical Name: 1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[(1S)-2-methoxy-1-phenylethylamino]ethanone
• CAS No.: 500317-68-0
• Molecular Formula: C₂₁H₂₅NO₄
• Molecular Weight: 355.434
• Mol file: 500317-68-0.mol

Synonyms:1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[(1S)-2-methoxy-1-phenylethylamino]ethanone

Chemical Property of 1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[(1S)-2-methoxy-1-phenylethylamino]ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[(1S)-2-methoxy-1-phenylethylamino]ethanone

There total 2 articles about 1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[(1S)-2-methoxy-1-phenylethylamino]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(S)-2-methoxy-1-phenylethylamine (91298-74-7) + 2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone (102293-80-1) → 1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[(1S)-2-methoxy-1-phenylethylamino]ethanone (500317-68-0)

Guidance literature:

With polystyryldiisopropylethylamine; In tetrahydrofuran; for 2h;

DOI:10.1039/b207068p

Reference yield:

(2S)-2-phenylglycinol (20989-17-7) → 1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[(1S)-2-methoxy-1-phenylethylamino]ethanone (500317-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 2 h

1.2: 88 percent / tetrahydrofuran / 2 h / Heating

2.1: 64 percent / polystyryldiisopropylethylamine / tetrahydrofuran / 2 h

With polystyryldiisopropylethylamine; sodium hydride; In tetrahydrofuran;

DOI:10.1039/b207068p

Reference yield: 91.0%

1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[(1S)-2-methoxy-1-phenylethylamino]ethanone (500317-68-0) → 1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[(1S)-2-methoxy-1-phenylethylamino]ethanol

Guidance literature:

With polystyryl(trimethyl)ammonium borohydride; calcium chloride; In methanol; at 0 - 20 ℃; for 2h;

DOI:10.1039/b207068p

upstream raw materials:

(S)-2-methoxy-1-phenylethylamine

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

(2S)-2-phenylglycinol