2-(2,3-Dichloro-4-Methoxyphenyl)acetaldehyde

Base Information

• Chemical Name: 2-(2,3-Dichloro-4-Methoxyphenyl)acetaldehyde
• CAS No.: 93135-13-8
• Molecular Formula: C₉H₈Cl₂O₂
• Molecular Weight: 219.067
• Mol file: 93135-13-8.mol

Synonyms:(2,3-dichloro-4-methoxyphenyl)acetaldehyde

Chemical Property of 2-(2,3-Dichloro-4-Methoxyphenyl)acetaldehyde

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

≥99% ^*data from raw suppliers

2-(2,3-Dichloro-4-methoxyphenyl)acetaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,3-Dichloro-4-Methoxyphenyl)acetaldehyde

There total 2 articles about 2-(2,3-Dichloro-4-Methoxyphenyl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dichloro-4-methoxy-benzaldehyde (41827-86-5) → (2,3-dichloro-4-methoxyphenyl)acetaldehyde (93135-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 g / NaOCH₃ / tetrahydrofuran; methanol / 2 h / 0 - 5 °C

2: 1.) NaOH, 2.)AcOH / 1.) THF/H₂O, RT, 1 h, 2.) toluene/H₂O, 80 deg C, 2 h

With sodium hydroxide; sodium methylate; acetic acid; In tetrahydrofuran; methanol;

DOI:10.1021/jm00379a016

Reference yield:

methyl 3-(2,3-dichloro-4-methoxyphenyl)oxirane-2-carboxylate (93135-42-3) → (2,3-dichloro-4-methoxyphenyl)acetaldehyde (93135-13-8)

Guidance literature:

With sodium hydroxide; acetic acid; Yield given. Multistep reaction; 1.) THF/H₂O, RT, 1 h, 2.) toluene/H₂O, 80 deg C, 2 h;

DOI:10.1021/jm00379a016

Reference yield: 100.0%

4-(trimethylsilyl)morpholine (13368-42-8) + (2,3-dichloro-4-methoxyphenyl)acetaldehyde (93135-13-8) → 1-morpholino-2-(2,3-dichloro-4-methoxyphenyl)ethene (93135-44-5)

Guidance literature:

With toluene-4-sulfonic acid; Ambient temperature;

DOI:10.1021/jm00379a016

upstream raw materials:

methyl 3-(2,3-dichloro-4-methoxyphenyl)oxirane-2-carboxylate

2,3-dichloro-4-methoxy-benzaldehyde

Downstream raw materials:

1-morpholino-2-(2,3-dichloro-4-methoxyphenyl)ethene

ethyl 2-hydroxy-5-(2,3-dichloro-4-methoxyphenyl)-1,5-cyclohexadienecarboxylate

Refernces