3-[(4'-{(R)-3-[3-((R)-2-Benzyloxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-propionic acid benzyl ester

Base Information

Chemical Name:3-[(4'-{(R)-3-[3-((R)-2-Benzyloxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-propionic acid benzyl ester
CAS No.:761377-71-3
Molecular Formula:C₄₉H₅₄N₄O₆
Molecular Weight:794.991
Hs Code.:

3-[(4'-{(R)-3-[3-((R)-2-Benzyloxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-propionic acid benzyl ester

Synonyms:3-[(4'-{(R)-3-[3-((R)-2-Benzyloxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-propionic acid benzyl ester

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Chemical Property of 3-[(4'-{(R)-3-[3-((R)-2-Benzyloxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-propionic acid benzyl ester

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Technology Process of 3-[(4'-{(R)-3-[3-((R)-2-Benzyloxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-propionic acid benzyl ester

There total 6 articles about 3-[(4'-{(R)-3-[3-((R)-2-Benzyloxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53346-05-7,41954-96-5,81445-44-5,81445-45-6
(R)-2-benzyloxypropanal

: 761377-71-3
3-[(4'-{(R)-3-[3-((R)-2-Benzyloxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 3-Angstroem molecular sieves, 2.) NaBH₃CN / 1.) methanol, pH 6, 2 h, r.t., 2.) methanol/THF, 72 h, r.t.

2: 92 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature

3: 98 percent / CF₃COOH/anisole / CH₂Cl₂ / 1.5 h / Ambient temperature

4: 375 mg / PyBOP / CH₂Cl₂ / 2 h / Ambient temperature

With 3 A molecular sieve; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydride; sodium cyanoborohydride; methoxybenzene; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800421

Reference yield:

: 145485-77-4
3-t-butoxy-carbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-butanamide

: 761377-71-3
3-[(4'-{(R)-3-[3-((R)-2-Benzyloxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / CF₃COOH / CH₂Cl₂ / 1 h / Ambient temperature

2: 1.) 3-Angstroem molecular sieves, 2.) NaBH₃CN / 1.) methanol, pH 6, 2 h, r.t., 2.) methanol/THF, 72 h, r.t.

3: 92 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature

4: 98 percent / CF₃COOH/anisole / CH₂Cl₂ / 1.5 h / Ambient temperature

5: 375 mg / PyBOP / CH₂Cl₂ / 2 h / Ambient temperature

With 3 A molecular sieve; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydride; sodium cyanoborohydride; methoxybenzene; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800421

Reference yield:

: 145486-32-4
3-amino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]butanamide

: 761377-71-3
3-[(4'-{(R)-3-[3-((R)-2-Benzyloxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 3-Angstroem molecular sieves, 2.) NaBH₃CN / 1.) methanol, pH 6, 2 h, r.t., 2.) methanol/THF, 72 h, r.t.

2: 92 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature

3: 98 percent / CF₃COOH/anisole / CH₂Cl₂ / 1.5 h / Ambient temperature

4: 375 mg / PyBOP / CH₂Cl₂ / 2 h / Ambient temperature

With 3 A molecular sieve; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydride; sodium cyanoborohydride; methoxybenzene; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800421