4-[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]-4,5-dihydro-5-oxo-6-[(phenylmethyl)amino]-2-pyrazinecarboxamide

Base Information

Chemical Name:4-[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]-4,5-dihydro-5-oxo-6-[(phenylmethyl)amino]-2-pyrazinecarboxamide
CAS No.:1095003-17-0
Molecular Formula:C₂₃H₂₃N₅O₃
Molecular Weight:417.467
Hs Code.:

Synonyms:4-[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]-4,5-dihydro-5-oxo-6-[(phenylmethyl)amino]-2-pyrazinecarboxamide

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Chemical Property of 4-[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]-4,5-dihydro-5-oxo-6-[(phenylmethyl)amino]-2-pyrazinecarboxamide

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Technology Process of 4-[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]-4,5-dihydro-5-oxo-6-[(phenylmethyl)amino]-2-pyrazinecarboxamide

There total 6 articles about 4-[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]-4,5-dihydro-5-oxo-6-[(phenylmethyl)amino]-2-pyrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095003-15-8
3-[5-cyano-2-oxo-3-[(phenylmethyl)amino]-1(2H)-pyrazinyl]-N-cyclopropyl-4-methyl-benzamide

: 1095003-17-0
4-[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]-4,5-dihydro-5-oxo-6-[(phenylmethyl)amino]-2-pyrazinecarboxamide

Guidance literature:: With ammonia; dihydrogen peroxide; In methanol; water; for 12h;

Reference yield:

: 1095005-58-5
methyl 3-[(cyanomethyl)amino]-4-methylbenzoate

: 1095003-17-0
4-[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]-4,5-dihydro-5-oxo-6-[(phenylmethyl)amino]-2-pyrazinecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1,2-dichloro-benzene / 4 h / 100 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

3: cyclopentylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.5 h / Microwave vial

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.17 h / 170 °C / Microwave irradiation

5: ammonia; dihydrogen peroxide / methanol; water / 12 h

With ammonia; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; cyclopentylmagnesium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide; 1,2-dichloro-benzene;

Reference yield:

: 1095005-59-6
methyl 3-(3,5-dibromo-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate

: 1095003-17-0
4-[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]-4,5-dihydro-5-oxo-6-[(phenylmethyl)amino]-2-pyrazinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

2: cyclopentylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.5 h / Microwave vial

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.17 h / 170 °C / Microwave irradiation

4: ammonia; dihydrogen peroxide / methanol; water / 12 h

With ammonia; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; cyclopentylmagnesium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide;