N-(1-(3-aminopropyl)piperidin-4-yl)-3,5-bis(4-carbamimidoylphenoxy)benzamide

Base Information

Chemical Name:N-(1-(3-aminopropyl)piperidin-4-yl)-3,5-bis(4-carbamimidoylphenoxy)benzamide
CAS No.:1256589-30-6
Molecular Formula:C₂₉H₃₅N₇O₃
Molecular Weight:529.642
Hs Code.:

Synonyms:N-(1-(3-aminopropyl)piperidin-4-yl)-3,5-bis(4-carbamimidoylphenoxy)benzamide

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Chemical Property of N-(1-(3-aminopropyl)piperidin-4-yl)-3,5-bis(4-carbamimidoylphenoxy)benzamide

Chemical Property:

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Technology Process of N-(1-(3-aminopropyl)piperidin-4-yl)-3,5-bis(4-carbamimidoylphenoxy)benzamide

There total 9 articles about N-(1-(3-aminopropyl)piperidin-4-yl)-3,5-bis(4-carbamimidoylphenoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1611481-65-2
C₃₄H₄₃N₇O₅

: 1256589-30-6
N-(1-(3-aminopropyl)piperidin-4-yl)-3,5-bis(4-carbamimidoylphenoxy)benzamide

Guidance literature:: With hydrogenchloride; ethanol; at 5 - 10 ℃; for 2h;
DOI:10.1016/j.bmc.2014.04.013

Reference yield:

: 1256592-62-7
(3-{4-[3,5-bis-(4-cyano-phenoxy)-benzoylamino]-piperidin-1-yl}-propyl)-carbamic acid tert-butyl ester

: 1256589-30-6
N-(1-(3-aminopropyl)piperidin-4-yl)-3,5-bis(4-carbamimidoylphenoxy)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine / ethanol; water / 6 h / 75 °C

2: acetic acid / 2 h / 20 °C

3: acetic acid; zinc / 20 °C

4: hydrogenchloride; ethanol / 2 h / 5 - 10 °C

With hydrogenchloride; ethanol; hydroxylamine; acetic acid; zinc; In ethanol; water;
DOI:10.1016/j.bmc.2014.04.013

Reference yield:

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 1256589-30-6
N-(1-(3-aminopropyl)piperidin-4-yl)-3,5-bis(4-carbamimidoylphenoxy)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 80 °C

2.1: lithium hydroxide; water / tetrahydrofuran / 2 h

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 5 °C

3.2: 20 °C

4.1: hydroxylamine / ethanol; water / 6 h / 75 °C

5.1: acetic acid / 2 h / 20 °C

6.1: acetic acid; zinc / 20 °C

7.1: hydrogenchloride; ethanol / 2 h / 5 - 10 °C

With hydrogenchloride; ethanol; water; hydroxylamine; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; zinc; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.04.013