(R)-3-phenyl-N¹-(8-phenylsulfanyl-2-pyridin-4-yl-pyrido[3,4-d]pyrimidin-4-yl)propane-1,2-diamine

Base Information

• Chemical Name: (R)-3-phenyl-N¹-(8-phenylsulfanyl-2-pyridin-4-yl-pyrido[3,4-d]pyrimidin-4-yl)propane-1,2-diamine
• CAS No.: 1588951-87-4
• Molecular Formula: C₂₇H₂₄N₆S
• Molecular Weight: 464.594

Synonyms:(R)-3-phenyl-N¹-(8-phenylsulfanyl-2-pyridin-4-yl-pyrido[3,4-d]pyrimidin-4-yl)propane-1,2-diamine

Chemical Property of (R)-3-phenyl-N¹-(8-phenylsulfanyl-2-pyridin-4-yl-pyrido[3,4-d]pyrimidin-4-yl)propane-1,2-diamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (R)-3-phenyl-N¹-(8-phenylsulfanyl-2-pyridin-4-yl-pyrido[3,4-d]pyrimidin-4-yl)propane-1,2-diamine

There total 4 articles about (R)-3-phenyl-N¹-(8-phenylsulfanyl-2-pyridin-4-yl-pyrido[3,4-d]pyrimidin-4-yl)propane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(S)-1-benzyl-2-(8-chloro-2-pyridin-4-ylpyrido[3,4-d]pyrimidin-4-ylamino)ethyl]carbamic acid tert-butyl ester (1589082-89-2) + thiophenol (108-98-5) → (R)-3-phenyl-N1-(8-phenylsulfanyl-2-pyridin-4-yl-pyrido[3,4-d]pyrimidin-4-yl)propane-1,2-diamine (1588951-87-4)

Guidance literature:

thiophenol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 1h;

[(S)-1-benzyl-2-(8-chloro-2-pyridin-4-ylpyrido[3,4-d]pyrimidin-4-ylamino)ethyl]carbamic acid tert-butyl ester; In N,N-dimethyl-formamide; mineral oil;

With trifluoroacetic acid; In dichloromethane; for 3h;

Reference yield:

8-chloro-2-(pyridin-4-yl)pyrido[3,4-d]pyrimidin-4-ol (1589081-51-5) → (R)-3-phenyl-N1-(8-phenylsulfanyl-2-pyridin-4-yl-pyrido[3,4-d]pyrimidin-4-yl)propane-1,2-diamine (1588951-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 2,4,6-triisopropylphenylsulfonyl chloride; triethylamine; dmap / N,N-dimethyl acetamide / 1 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h

2.3: 3 h

With dmap; 2,4,6-triisopropylphenylsulfonyl chloride; sodium hydride; triethylamine; In N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

2-chloro-3-[(pyridine-4-carbonyl)amino]isonicotinamide (1589081-56-0) → (R)-3-phenyl-N1-(8-phenylsulfanyl-2-pyridin-4-yl-pyrido[3,4-d]pyrimidin-4-yl)propane-1,2-diamine (1588951-87-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: caesium carbonate / methanol; water / 20 °C

2.1: 2,4,6-triisopropylphenylsulfonyl chloride; triethylamine; dmap / N,N-dimethyl acetamide / 1 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h

3.3: 3 h

With dmap; 2,4,6-triisopropylphenylsulfonyl chloride; sodium hydride; caesium carbonate; triethylamine; In methanol; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

[(S)-1-benzyl-2-(8-chloro-2-pyridin-4-ylpyrido[3,4-d]pyrimidin-4-ylamino)ethyl]carbamic acid tert-butyl ester

thiophenol

8-chloro-2-(pyridin-4-yl)pyrido[3,4-d]pyrimidin-4-ol

3-amino-2-chloropyridine-4-carboxamide

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