ethyl 2-(10-(4-methylphenylsulfonamido)-5-tosyl-5,6-dihydrophenanthridin-6-yl)acetate

Base Information

• Chemical Name: ethyl 2-(10-(4-methylphenylsulfonamido)-5-tosyl-5,6-dihydrophenanthridin-6-yl)acetate
• CAS No.: 1330574-25-8
• Molecular Formula: C₃₁H₃₀N₂O₆S₂
• Molecular Weight: 590.721
• Mol file: 1330574-25-8.mol

Synonyms:ethyl 2-(10-(4-methylphenylsulfonamido)-5-tosyl-5,6-dihydrophenanthridin-6-yl)acetate

Chemical Property of ethyl 2-(10-(4-methylphenylsulfonamido)-5-tosyl-5,6-dihydrophenanthridin-6-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(10-(4-methylphenylsulfonamido)-5-tosyl-5,6-dihydrophenanthridin-6-yl)acetate

There total 3 articles about ethyl 2-(10-(4-methylphenylsulfonamido)-5-tosyl-5,6-dihydrophenanthridin-6-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

N,N'-([1,1'-biphenyl]-2,2'-diyl)bis(4-methylbenzenesulfonamide) (173044-24-1) + ethyl acrylate (140-88-5,9003-32-1) → ethyl 2-(10-(4-methylphenylsulfonamido)-5-tosyl-5,6-dihydrophenanthridin-6-yl)acetate (1330574-25-8)

Guidance literature:

With dipotassium peroxodisulfate; palladium diacetate; toluene-4-sulfonic acid; trifluoroacetic acid; In dichloromethane; at 25 ℃; for 4h; regioselective reaction;

DOI:10.1002/asia.201100024

Reference yield:

1,1'-biphenyl-2,2'-diamine (1454-80-4) → ethyl 2-(10-(4-methylphenylsulfonamido)-5-tosyl-5,6-dihydrophenanthridin-6-yl)acetate (1330574-25-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 2 h / 0 - 25 °C

2: dipotassium peroxodisulfate; palladium diacetate; toluene-4-sulfonic acid; trifluoroacetic acid / dichloromethane / 4 h / 25 °C

With pyridine; dipotassium peroxodisulfate; palladium diacetate; toluene-4-sulfonic acid; trifluoroacetic acid; In dichloromethane;

DOI:10.1002/asia.201100024

Reference yield:

1-nitro-2-(2-nitrophenyl)benzene (2436-96-6) → ethyl 2-(10-(4-methylphenylsulfonamido)-5-tosyl-5,6-dihydrophenanthridin-6-yl)acetate (1330574-25-8)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen / ethanol / 3 h / 20 °C

2: pyridine / 2 h / 0 - 25 °C

3: dipotassium peroxodisulfate; palladium diacetate; toluene-4-sulfonic acid; trifluoroacetic acid / dichloromethane / 4 h / 25 °C

With pyridine; dipotassium peroxodisulfate; palladium on activated charcoal; hydrogen; palladium diacetate; toluene-4-sulfonic acid; trifluoroacetic acid; In ethanol; dichloromethane;

DOI:10.1002/asia.201100024

upstream raw materials:

1-nitro-2-(2-nitrophenyl)benzene

1,1'-biphenyl-2,2'-diamine

N,N'-([1,1'-biphenyl]-2,2'-diyl)bis(4-methylbenzenesulfonamide)

ethyl acrylate