4-[N-(3-chloro-4-fluorophenyl)amino]-6-fluoro-7-[4-(4-morpholinyl)butyl]pyrido[3,2-d]pyrimidine

Base Information

Chemical Name:4-[N-(3-chloro-4-fluorophenyl)amino]-6-fluoro-7-[4-(4-morpholinyl)butyl]pyrido[3,2-d]pyrimidine
CAS No.:267243-54-9
Molecular Formula:C₂₁H₂₂ClF₂N₅O
Molecular Weight:433.888
Hs Code.:

Synonyms:4-[N-(3-chloro-4-fluorophenyl)amino]-6-fluoro-7-[4-(4-morpholinyl)butyl]pyrido[3,2-d]pyrimidine

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Chemical Property of 4-[N-(3-chloro-4-fluorophenyl)amino]-6-fluoro-7-[4-(4-morpholinyl)butyl]pyrido[3,2-d]pyrimidine

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Technology Process of 4-[N-(3-chloro-4-fluorophenyl)amino]-6-fluoro-7-[4-(4-morpholinyl)butyl]pyrido[3,2-d]pyrimidine

There total 11 articles about 4-[N-(3-chloro-4-fluorophenyl)amino]-6-fluoro-7-[4-(4-morpholinyl)butyl]pyrido[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 267243-52-7
4-[N-(3-chloro-4-fluorophenyl)amino]-6-fluoro-7-[(1E)-4-(4-morpholinyl)-1-butenyl]pyrido[3,2-d]pyrimidine

: 267243-54-9
4-[N-(3-chloro-4-fluorophenyl)amino]-6-fluoro-7-[4-(4-morpholinyl)butyl]pyrido[3,2-d]pyrimidine

Guidance literature:: With hydrogen; platinum(IV) oxide; In tetrahydrofuran; methanol; for 18h; under 3102.97 Torr;
DOI:10.1021/jm990482t

Reference yield:

: 367-21-5
3-chloro-4-fluorophenylamine

: 267243-54-9
4-[N-(3-chloro-4-fluorophenyl)amino]-6-fluoro-7-[4-(4-morpholinyl)butyl]pyrido[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. HCl / propan-2-ol / 0.5 h / 60 °C

2.1: tributyltin hydride; AIBN / 16 h / 90 °C

2.2: tetrakistriphenylphosphinepalladium⁽⁰⁾ / dimethylformamide / 1.25 h / 100 °C

3.1: 94 percent / H₂ / PtO₂*xH₂O / methanol; tetrahydrofuran / 18 h / 3102.97 Torr

With hydrogenchloride; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; platinum(IV) oxide; In tetrahydrofuran; methanol; isopropyl alcohol; 1.1: Condensation / 2.1: stannylation / 2.2: alkenylation / 3.1: Catalytic hydrogenation;
DOI:10.1021/jm990482t

Reference yield:

: 171178-21-5
6-chloro-3-nitropyridine-2-carboxamide

: 267243-54-9
4-[N-(3-chloro-4-fluorophenyl)amino]-6-fluoro-7-[4-(4-morpholinyl)butyl]pyrido[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 9 steps

1.1: 73 percent / aq. NH₃ / ethanol / 20 h / 100 °C

2.1: 84 percent / AcOH; KOAc / 1.5 h / 20 °C

3.1: Fe; aq. HOAc / ethanol / 0.5 h / Heating

4.1: ethanol / 3 h / Heating

5.1: 54 percent / 50percent aq. HBF₄; NaNO₂ / -20 - -10 °C

6.1: POCl₃ / 1.83 h / Heating

7.1: aq. HCl / propan-2-ol / 0.5 h / 60 °C

8.1: tributyltin hydride; AIBN / 16 h / 90 °C

8.2: tetrakistriphenylphosphinepalladium⁽⁰⁾ / dimethylformamide / 1.25 h / 100 °C

9.1: 94 percent / H₂ / PtO₂*xH₂O / methanol; tetrahydrofuran / 18 h / 3102.97 Torr

With hydrogenchloride; ammonium hydroxide; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; potassium acetate; iron; acetic acid; sodium nitrite; trichlorophosphate; platinum(IV) oxide; In tetrahydrofuran; methanol; ethanol; isopropyl alcohol; 1.1: Substitution / 2.1: Bromination / 3.1: Reduction / 4.1: cyclocondensation / 5.1: Fluorination / 6.1: Chlorination / 7.1: Condensation / 8.1: stannylation / 8.2: alkenylation / 9.1: Catalytic hydrogenation;
DOI:10.1021/jm990482t