N-[1-(2'-azido-1'(S)-hydroxy)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester

Base Information

• Chemical Name: N-[1-(2'-azido-1'(S)-hydroxy)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester
• CAS No.: 264921-86-0
• Molecular Formula: C₂₁H₃₁N₅O₅
• Molecular Weight: 433.508

Synonyms:N-[1-(2'-azido-1'(S)-hydroxy)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester

Chemical Property of N-[1-(2'-azido-1'(S)-hydroxy)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester

Chemical Property:

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Technology Process of N-[1-(2'-azido-1'(S)-hydroxy)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester

There total 3 articles about N-[1-(2'-azido-1'(S)-hydroxy)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-Phe-Leu (3303-55-7) → N-[1-(2'-azido-1'(S)-hydroxy)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester (264921-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Me₃Al / hexane; 1,2-dichloro-ethane / 24 h / Heating

2: diethyl ether

With trimethylaluminum; In diethyl ether; hexane; 1,2-dichloro-ethane; 1: Ring cleavage / 2: Esterification;

DOI:10.1021/jo991288h

Reference yield:

(S)-(+)-5-Azidomethyl-2-oxotetrahydrofuran (24211-53-8) → N-[1-(2'-azido-1'(S)-hydroxy)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester (264921-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Me₃Al / hexane; 1,2-dichloro-ethane / 24 h / Heating

2: diethyl ether

With trimethylaluminum; In diethyl ether; hexane; 1,2-dichloro-ethane; 1: Ring cleavage / 2: Esterification;

DOI:10.1021/jo991288h

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + N-[1-(2'-azido-1'(S)-hydroxy)butylcarboxy]-L-phenylalanyl-L-leucine (264921-75-7) → N-[1-(2'-azido-1'(S)-hydroxy)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester (264921-86-0)

Guidance literature:

In diethyl ether;

DOI:10.1021/jo991288h

upstream raw materials:

diazomethane

N-[1-(2'-azido-1'(S)-hydroxy)butylcarboxy]-L-phenylalanyl-L-leucine

L-Phe-Leu

(S)-(+)-5-Azidomethyl-2-oxotetrahydrofuran

Downstream raw materials:

N-[1-(2'-[N-tert-butoxycarbonyl-L-tyrosyl]amino-1'(S)-hydroxy)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester

N-[1-(2'-amino-1'(S)-hydroxy)butylcarboxy]-L-phenylalanyl-L-leucyl methyl ester

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