methyl 5-O-(2,3-di-O-benzyl-5-O-(2-O-benzoyl-3,5-di-O-benzyl-α-D-arabinofuranosyl)-α-D-arabinofuranozyl)-2,3-di-O-benzyl-α-D-arabinofuranoside

Base Information

Chemical Name:methyl 5-O-(2,3-di-O-benzyl-5-O-(2-O-benzoyl-3,5-di-O-benzyl-α-D-arabinofuranosyl)-α-D-arabinofuranozyl)-2,3-di-O-benzyl-α-D-arabinofuranoside
CAS No.:402758-99-0
Molecular Formula:C₆₅H₆₈O₁₄
Molecular Weight:1073.25
Hs Code.:

Synonyms:methyl 5-O-(2,3-di-O-benzyl-5-O-(2-O-benzoyl-3,5-di-O-benzyl-α-D-arabinofuranosyl)-α-D-arabinofuranozyl)-2,3-di-O-benzyl-α-D-arabinofuranoside

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Chemical Property of methyl 5-O-(2,3-di-O-benzyl-5-O-(2-O-benzoyl-3,5-di-O-benzyl-α-D-arabinofuranosyl)-α-D-arabinofuranozyl)-2,3-di-O-benzyl-α-D-arabinofuranoside

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Technology Process of methyl 5-O-(2,3-di-O-benzyl-5-O-(2-O-benzoyl-3,5-di-O-benzyl-α-D-arabinofuranosyl)-α-D-arabinofuranozyl)-2,3-di-O-benzyl-α-D-arabinofuranoside

There total 9 articles about methyl 5-O-(2,3-di-O-benzyl-5-O-(2-O-benzoyl-3,5-di-O-benzyl-α-D-arabinofuranosyl)-α-D-arabinofuranozyl)-2,3-di-O-benzyl-α-D-arabinofuranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 402758-78-5
p-cresyl 2-O-benzoyl-3,5-di-O-benzyl-1-thio-α-D-arabinofuranoside

: 402758-98-9
methyl 2,3-di-O-benzyl-α-D-arabinofuranosyl-(1->5)-2,3-di-O-benzyl-α-D-arabinofuranoside

: 402758-99-0
methyl 5-O-(2,3-di-O-benzyl-5-O-(2-O-benzoyl-3,5-di-O-benzyl-α-D-arabinofuranosyl)-α-D-arabinofuranozyl)-2,3-di-O-benzyl-α-D-arabinofuranoside

Guidance literature:: With N-iodo-succinimide; molecular sieve; silver trifluoromethanesulfonate; In dichloromethane; at 0 ℃;
DOI:10.1021/jo010910e

Reference yield:

: 16896-03-0,16896-04-1,30589-89-0,53496-31-4,70831-62-8,103476-40-0,128821-26-1
methyl 2,3-di-O-benzyl-α-D-arabinofuranoside

: 402758-99-0
methyl 5-O-(2,3-di-O-benzyl-5-O-(2-O-benzoyl-3,5-di-O-benzyl-α-D-arabinofuranosyl)-α-D-arabinofuranozyl)-2,3-di-O-benzyl-α-D-arabinofuranoside

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / molecular sieves; NIS; AgOTf / CH₂Cl₂ / 0 °C

2: 95 percent / NaOCH₃ / methanol / 2 h / 20 °C

3: pyridine / 20 °C

4: NaH / dimethylformamide / 2 h / 0 °C

5: 910 mg / p-TsOH / methanol; CH₂Cl₂ / 20 °C

6: 88 percent / molecular sieves; NIS; AgOTf / CH₂Cl₂ / 0 °C

With N-iodo-succinimide; molecular sieve; sodium methylate; silver trifluoromethanesulfonate; sodium hydride; toluene-4-sulfonic acid; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; 2: Zemplen deacylation;
DOI:10.1021/jo010910e

Reference yield:

: 329360-22-7
1-O-methyl-3,5-di-O-benzyl-α-D-arabinofuranose

: 402758-99-0
methyl 5-O-(2,3-di-O-benzyl-5-O-(2-O-benzoyl-3,5-di-O-benzyl-α-D-arabinofuranosyl)-α-D-arabinofuranozyl)-2,3-di-O-benzyl-α-D-arabinofuranoside

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / pyridine / 2 h / 20 °C

2: 72 percent / BF₃*OEt₂ / CH₂Cl₂ / 2 h / 0 °C

3: 88 percent / molecular sieves; NIS; AgOTf / CH₂Cl₂ / 0 °C

With N-iodo-succinimide; molecular sieve; boron trifluoride diethyl etherate; silver trifluoromethanesulfonate; In pyridine; dichloromethane;
DOI:10.1021/jo010910e