Technology Process of (2S)-4-hydroxybutan-2-yl 4-methoxy-2-(methoxymethoxy)-6-[(1E)-3-oxoprop-1-en-1-yl]benzoate
There total 5 articles about (2S)-4-hydroxybutan-2-yl 4-methoxy-2-(methoxymethoxy)-6-[(1E)-3-oxoprop-1-en-1-yl]benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
dichloromethane;
at 20 ℃;
for 3h;
pH=7.6;
aq. phosphate buffer;
DOI:10.1016/j.tet.2012.04.082
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium hydroxide / water / 1.5 h / 20 °C
2.1: pyridine / 3 h / 20 °C / Inert atmosphere
3.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / propan-1-ol / 4.5 h / Reflux
4.1: sodium hydroxide / methanol; water / Reflux
4.2: pH 5
5.1: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 0.5 h / Inert atmosphere
6.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 3 h / 20 °C / pH 7.6 / aq. phosphate buffer
With
pyridine; bis-triphenylphosphine-palladium(II) chloride; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; lithium hydroxide;
In
methanol; propan-1-ol; dichloromethane; water; toluene;
3.1: Suzuki-Miyaura type coupling / 5.1: Mitsunobu reaction;
DOI:10.1016/j.tet.2012.04.082
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / 20 °C
2.1: lithium hydroxide / water / 1.5 h / 20 °C
3.1: pyridine / 3 h / 20 °C / Inert atmosphere
4.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / propan-1-ol / 4.5 h / Reflux
5.1: sodium hydroxide / methanol; water / Reflux
5.2: pH 5
6.1: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 0.5 h / Inert atmosphere
7.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 3 h / 20 °C / pH 7.6 / aq. phosphate buffer
With
pyridine; bis-triphenylphosphine-palladium(II) chloride; di-isopropyl azodicarboxylate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; lithium hydroxide;
In
methanol; propan-1-ol; dichloromethane; water; toluene;
4.1: Suzuki-Miyaura type coupling / 6.1: Mitsunobu reaction;
DOI:10.1016/j.tet.2012.04.082
