[8-(2-benzyloxycarbonylamino-ethoxy)-2-oxo-2,9-dihydro-10-oxa-1,3,9-triaza-anthracen-3-yl]-acetic acid tert-butyl ester

Base Information

• Chemical Name: [8-(2-benzyloxycarbonylamino-ethoxy)-2-oxo-2,9-dihydro-10-oxa-1,3,9-triaza-anthracen-3-yl]-acetic acid tert-butyl ester
• CAS No.: 476667-25-1
• Molecular Formula: C₂₆H₂₈N₄O₇
• Molecular Weight: 508.531
• Mol file: 476667-25-1.mol

Synonyms:[8-(2-benzyloxycarbonylamino-ethoxy)-2-oxo-2,9-dihydro-10-oxa-1,3,9-triaza-anthracen-3-yl]-acetic acid tert-butyl ester

Chemical Property of [8-(2-benzyloxycarbonylamino-ethoxy)-2-oxo-2,9-dihydro-10-oxa-1,3,9-triaza-anthracen-3-yl]-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [8-(2-benzyloxycarbonylamino-ethoxy)-2-oxo-2,9-dihydro-10-oxa-1,3,9-triaza-anthracen-3-yl]-acetic acid tert-butyl ester

There total 8 articles about [8-(2-benzyloxycarbonylamino-ethoxy)-2-oxo-2,9-dihydro-10-oxa-1,3,9-triaza-anthracen-3-yl]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

C26H29BrN4O7 → [8-(2-benzyloxycarbonylamino-ethoxy)-2-oxo-2,9-dihydro-10-oxa-1,3,9-triaza-anthracen-3-yl]-acetic acid tert-butyl ester (476667-25-1)

Guidance literature:

With cesium fluoride; In ethanol; at 80 ℃; for 17h;

DOI:10.1021/ol701826x

Reference yield: 40.0%

benzyl 2-hydroxyethylcarbamate (77987-49-6) + (8-hydroxy-2-oxo-2,9-dihydro-10-oxa-1,3,9-triaza-anthracen-3-yl)-acetic acid tert-butyl ester (476667-24-0) → [8-(2-benzyloxycarbonylamino-ethoxy)-2-oxo-2,9-dihydro-10-oxa-1,3,9-triaza-anthracen-3-yl]-acetic acid tert-butyl ester (476667-25-1)

Guidance literature:

With Ph₂PC₆H₄-polymer; diethylazodicarboxylate; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/ol026815p

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) → [8-(2-benzyloxycarbonylamino-ethoxy)-2-oxo-2,9-dihydro-10-oxa-1,3,9-triaza-anthracen-3-yl]-acetic acid tert-butyl ester (476667-25-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 85 percent / K₂CO₃ / dimethylformamide / 21 h / 20 °C

2.1: POCl₃; TEA / acetonitrile / 0.5 h / 0 °C

2.2: 90 percent / acetonitrile / 21 h / 20 °C

3.1: 80 percent / DBU / acetonitrile / 20 h / 20 °C

4.1: 76 percent / KF / ethanol / 20 h / Heating

5.1: 40 percent / DEAD; Ph₂PC₆H₄-polymer / CH₂Cl₂ / 4 h / 20 °C

With potassium fluoride; Ph₂PC₆H₄-polymer; TEA; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; diethylazodicarboxylate; trichlorophosphate; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 5.1: Mitsunobu alkylation;

DOI:10.1021/ol026815p

upstream raw materials:

benzyl 2-hydroxyethylcarbamate

(8-hydroxy-2-oxo-2,9-dihydro-10-oxa-1,3,9-triaza-anthracen-3-yl)-acetic acid tert-butyl ester

bromoacetic acid tert-butyl ester

2-nitroresorcinol

Downstream raw materials:

{{[8-(2-benzyloxycarbonylamino-ethoxy)-2-oxo-2,9-dihydro-10-oxa-1,3,9-triaza-anthracen-3-yl]-acetyl}-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-amino}-acetic acid tert-butyl ester