(R)-tert-butyl 1-(benzylamino)-1-oxo-3-phenylpropan-2-ylcarbamate

Base Information

• Chemical Name: (R)-tert-butyl 1-(benzylamino)-1-oxo-3-phenylpropan-2-ylcarbamate
• CAS No.: 114530-49-3
• Molecular Formula: C₂₁H₂₆N₂O₃
• Molecular Weight: 354.449
• Mol file: 114530-49-3.mol

Synonyms:(R)-tert-butyl 1-(benzylamino)-1-oxo-3-phenylpropan-2-ylcarbamate

Chemical Property of (R)-tert-butyl 1-(benzylamino)-1-oxo-3-phenylpropan-2-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl 1-(benzylamino)-1-oxo-3-phenylpropan-2-ylcarbamate

There total 36 articles about (R)-tert-butyl 1-(benzylamino)-1-oxo-3-phenylpropan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + benzylamine (100-46-9) → (S)-N-Boc-phenylalanine benzylamide (33662-25-8,114530-49-3,84235-32-5)

Guidance literature:

With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

Reference yield: 92.0%

Boc-Phe-ONSu (3674-06-4) + benzylamine (100-46-9) → (S)-N-Boc-phenylalanine benzylamide (33662-25-8,114530-49-3,84235-32-5)

Guidance literature:

In dichloromethane; at 0 ℃; for 1h;

DOI:10.1002/hlca.19950780305

Reference yield: 89.0%

(+/-)-2-tert-butoxycarbonylamino-3-phenyl-thiopropionic acid ethyl ester + benzylamine (100-46-9) → (S)-N-Boc-phenylalanine benzylamide (33662-25-8,114530-49-3,84235-32-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tert-butyl alcohol; at 37 ℃; for 5h; optical yield given as %ee; Resolution of racemate; Enzymatic reaction;

DOI:10.1002/adsc.201100389

upstream raw materials:

(S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanethioic S-acid

benzyl azide

Boc-Phe-O-COO-isoBu

benzylamine

Downstream raw materials:

(S)-2-((S)-1-Benzylcarbamoyl-2-phenyl-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

[(S)-2-[(S)-2-((S)-1-Benzylcarbamoyl-2-phenyl-ethylcarbamoyl)-pyrrolidin-1-yl]-1-(4-hydroxy-2,6-dimethyl-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester