1-(1-(2-benzodioxanylmethyl)-4-piperidiyl)amino-3-(1-naphthoxy)-2-propanol

Base Information

Chemical Name:1-(1-(2-benzodioxanylmethyl)-4-piperidiyl)amino-3-(1-naphthoxy)-2-propanol
CAS No.:131184-64-0
Molecular Formula:C₂₇H₃₂N₂O₄
Molecular Weight:448.562
Hs Code.:
Mol file:131184-64-0.mol

Synonyms:1,4-Benzodioxin,2-propanol deriv.

Suppliers and Price of 1-(1-(2-benzodioxanylmethyl)-4-piperidiyl)amino-3-(1-naphthoxy)-2-propanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 1-(1-(2-benzodioxanylmethyl)-4-piperidiyl)amino-3-(1-naphthoxy)-2-propanol

Chemical Property:

Vapor Pressure:7.36E-18mmHg at 25°C
Boiling Point:651.5°Cat760mmHg
Flash Point:347.8°C
PSA：63.19000
Density:1.26g/cm³
LogP:3.80230

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-(1-(2-benzodioxanylmethyl)-4-piperidiyl)amino-3-(1-naphthoxy)-2-propanol

There total 12 articles about 1-(1-(2-benzodioxanylmethyl)-4-piperidiyl)amino-3-(1-naphthoxy)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 2461-42-9
3-(1-naphthyloxy)-1,2-epoxypropane

: 89483-72-7
1-(2-benzodioxanylmethyl)-4-piperidylamine

: 131184-64-0
1-<1-(2-benzodioxanylmethyl)-4-piperidyl>amino-3-(1-naphthoxy)-2-propanol

Guidance literature:: In isopropyl alcohol; for 2.5h; Heating;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 131184-64-0
1-<1-(2-benzodioxanylmethyl)-4-piperidyl>amino-3-(1-naphthoxy)-2-propanol

Guidance literature:: Multi-step reaction with 9 steps

1: 70 percent / CHCl₃ / 16 h / Ambient temperature

2: 85 percent / p-toluenesulfonic acid / toluene / 24 h / Heating

3: potassium hydroxide / H₂O / 6 h / Heating

4: H₂O; CHCl₃ / 2 h / 20 °C

5: LiAlH₄ / tetrahydrofuran / 12 h / Heating

6: 6N HCl / H₂O / 12 h / Ambient temperature

7: 9 percent / hydroxylamine hydrochloride, sodium acetate / methanol / 8 h / Ambient temperature

8: LiAlH₄ / tetrahydrofuran; diethyl ether / 3 h / Heating

9: 68 percent / propan-2-ol / 2.5 h / Heating

With hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; hydroxylamine hydrochloride; sodium acetate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; chloroform; water; isopropyl alcohol; toluene;

Reference yield:

: 53491-24-0
8-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-1,4-dioxa-8-aza-spiro[4.5]decane

: 131184-64-0
1-<1-(2-benzodioxanylmethyl)-4-piperidyl>amino-3-(1-naphthoxy)-2-propanol

Guidance literature:: Multi-step reaction with 4 steps

1: 6N HCl / H₂O / 12 h / Ambient temperature

2: 9 percent / hydroxylamine hydrochloride, sodium acetate / methanol / 8 h / Ambient temperature

3: LiAlH₄ / tetrahydrofuran; diethyl ether / 3 h / Heating

4: 68 percent / propan-2-ol / 2.5 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; hydroxylamine hydrochloride; sodium acetate; In tetrahydrofuran; methanol; diethyl ether; water; isopropyl alcohol;