Technology Process of 5,16,27-Tris-benzyloxy-1,5,12,16,23,27-hexaaza-cyclotritriacontane-2,6,13,17,24,28-hexaone
There total 12 articles about 5,16,27-Tris-benzyloxy-1,5,12,16,23,27-hexaaza-cyclotritriacontane-2,6,13,17,24,28-hexaone which
guide to synthetic route it.
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synthetic route:
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97222-27-0
5,16,27-Tris-benzyloxy-1,5,12,16,23,27-hexaaza-cyclotritriacontane-2,6,13,17,24,28-hexaone
- Guidance literature:
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Multi-step reaction with 11 steps
1: 93 percent / ClCO2Bu-i, Et3N / 1.) -15 deg C, 5 h, 2.) r.t., 20 h
2: 4 M HCl / dioxane / 2 h / Ambient temperature
3: 77 percent / Et3N / dimethylformamide / 30 h / 30 °C
4: 97 percent / ClCO2Bu-i, Et3N / 1.) -15 deg C, 5 h, 2.) r.t., 20 h
5: 4 M HCl / dioxane / 2 h / Ambient temperature
6: 93 percent / Et3N / dimethylformamide / 30 h / 30 °C
7: 93 percent / ClCO2Bu-i, Et3N / 1.) -15 deg C, 5 h, 2.) r.t., 20 h
8: 1 M NaOH / methanol / 5 h / Ambient temperature
9: N-ethyl-N'-(3-dimethylaminopropyl)carbodi-imide / 1.) -5 deg C, 2 h, 2.) 5 deg C, 12 h
10: 0.5 h / 0 °C
11: pyridine / dimethylformamide / 12 h / Ambient temperature
With
pyridine; hydrogenchloride; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isobutyl chloroformate;
In
1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1039/c39850000183
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97222-27-0
5,16,27-Tris-benzyloxy-1,5,12,16,23,27-hexaaza-cyclotritriacontane-2,6,13,17,24,28-hexaone
- Guidance literature:
-
With
pyridine;
In
N,N-dimethyl-formamide;
for 12h;
Yield given;
Ambient temperature;
DOI:10.1039/c39850000183
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97222-27-0
5,16,27-Tris-benzyloxy-1,5,12,16,23,27-hexaaza-cyclotritriacontane-2,6,13,17,24,28-hexaone
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 93 percent / ClCO2Bu-i, Et3N / 1.) -15 deg C, 5 h, 2.) r.t., 20 h
2: 4 M HCl / dioxane / 2 h / Ambient temperature
3: 77 percent / Et3N / dimethylformamide / 30 h / 30 °C
4: 97 percent / ClCO2Bu-i, Et3N / 1.) -15 deg C, 5 h, 2.) r.t., 20 h
5: 4 M HCl / dioxane / 2 h / Ambient temperature
6: 93 percent / Et3N / dimethylformamide / 30 h / 30 °C
7: 93 percent / ClCO2Bu-i, Et3N / 1.) -15 deg C, 5 h, 2.) r.t., 20 h
8: 1 M NaOH / methanol / 5 h / Ambient temperature
9: N-ethyl-N'-(3-dimethylaminopropyl)carbodi-imide / 1.) -5 deg C, 2 h, 2.) 5 deg C, 12 h
10: 0.5 h / 0 °C
11: pyridine / dimethylformamide / 12 h / Ambient temperature
With
pyridine; hydrogenchloride; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isobutyl chloroformate;
In
1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1039/c39850000183
