{1,1-Difluoro-2-hydroxy-2-[4-(5,6,7,8-tetrahydro-naphthalen-1-yloxy)-phenyl]-ethyl}-phosphonic acid diethyl ester

Base Information

• Chemical Name: {1,1-Difluoro-2-hydroxy-2-[4-(5,6,7,8-tetrahydro-naphthalen-1-yloxy)-phenyl]-ethyl}-phosphonic acid diethyl ester
• CAS No.: 181059-94-9
• Molecular Formula: C₂₂H₂₇F₂O₅P
• Molecular Weight: 440.424

Synonyms:{1,1-Difluoro-2-hydroxy-2-[4-(5,6,7,8-tetrahydro-naphthalen-1-yloxy)-phenyl]-ethyl}-phosphonic acid diethyl ester

Chemical Property of {1,1-Difluoro-2-hydroxy-2-[4-(5,6,7,8-tetrahydro-naphthalen-1-yloxy)-phenyl]-ethyl}-phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {1,1-Difluoro-2-hydroxy-2-[4-(5,6,7,8-tetrahydro-naphthalen-1-yloxy)-phenyl]-ethyl}-phosphonic acid diethyl ester

There total 4 articles about {1,1-Difluoro-2-hydroxy-2-[4-(5,6,7,8-tetrahydro-naphthalen-1-yloxy)-phenyl]-ethyl}-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5,6,7,8-Tetrahydronaphthalen-1-ol (529-35-1) → {1,1-Difluoro-2-hydroxy-2-[4-(5,6,7,8-tetrahydro-naphthalen-1-yloxy)-phenyl]-ethyl}-phosphonic acid diethyl ester (181059-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / NaH / dimethylformamide / 2 h / 70 °C

2: 1.) LDA, 2.) AcOH / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, -78 deg C to rt

With sodium hydride; acetic acid; lithium diisopropyl amide; In N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(98)00148-5

Reference yield:

4-fluorobenzaldehyde (459-57-4) → {1,1-Difluoro-2-hydroxy-2-[4-(5,6,7,8-tetrahydro-naphthalen-1-yloxy)-phenyl]-ethyl}-phosphonic acid diethyl ester (181059-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / NaH / dimethylformamide / 2 h / 70 °C

2: 1.) LDA, 2.) AcOH / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, -78 deg C to rt

With sodium hydride; acetic acid; lithium diisopropyl amide; In N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(98)00148-5

Reference yield:

diethyl difluoromethylphosphonate lithium salt (94993-99-4,83567-74-2) + 4-(5,6,7,8-tetrahydronaphthyloxy)benzaldehyde (181059-89-2) → {1,1-Difluoro-2-hydroxy-2-[4-(5,6,7,8-tetrahydro-naphthalen-1-yloxy)-phenyl]-ethyl}-phosphonic acid diethyl ester (181059-94-9)

Guidance literature:

With acetic acid; Yield given. Multistep reaction; 1.) THF, -78 deg C; 2.) -78 deg C;

DOI:10.1016/0040-4039(96)00947-1

upstream raw materials:

diethyl difluoromethylphosphonate lithium salt

4-(5,6,7,8-tetrahydronaphthyloxy)benzaldehyde

Diethyl difluoromethylphosphonate

5,6,7,8-Tetrahydronaphthalen-1-ol

Downstream raw materials:

{1,1-Difluoro-2-oxo-2-[4-(5,6,7,8-tetrahydro-naphthalen-1-yloxy)-phenyl]-ethyl}-phosphonic acid diethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 181059-94-9 {1,1-Difluoro-2-hydroxy-2-[4-(5,6,7,8-tetrahydro-naphthalen-1-yloxy)-phenyl]-ethyl}-phosphonic acid diethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send