Methyl 2-(4-fluorophenyl)oxazole-4-carboxylate

Base Information

Chemical Name:Methyl 2-(4-fluorophenyl)oxazole-4-carboxylate
CAS No.:1065102-64-8
Molecular Formula:C₁₁H₈FNO₃
Molecular Weight:221.188
Hs Code.:
DSSTox Substance ID:DTXSID40693657
Nikkaji Number:J2.865.248H
Wikidata:Q82622669
ChEMBL ID:CHEMBL1997016

Synonyms:1065102-64-8;METHYL 2-(4-FLUOROPHENYL)OXAZOLE-4-CARBOXYLATE;methyl 2-(4-fluorophenyl)-1,3-oxazole-4-carboxylate;4-Oxazolecarboxylic acid, 2-(4-fluorophenyl)-, methyl ester;SCHEMBL2221957;CHEMBL1997016;DTXSID40693657;DBAOBCFFEKYUQI-UHFFFAOYSA-N;MFCD16875490;MLS-0466676.0001;A911253;METHYL2-(4-FLUOROPHENYL)OXAZOLE-4-CARBOXYLATE;2-(4-Fluorophenyl)-4-oxazolecarboxylic acid methyl ester

Suppliers and Price of Methyl 2-(4-fluorophenyl)oxazole-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl2-(4-fluorophenyl)oxazole-4-carboxylate 95+%
1g
$ 413.00

Total 2 raw suppliers

Chemical Property of Methyl 2-(4-fluorophenyl)oxazole-4-carboxylate

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:221.04882128
Heavy Atom Count:16
Complexity:254

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-(4-fluorophenyl)oxazole-4-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=COC(=N1)C2=CC=C(C=C2)F

Technology Process of Methyl 2-(4-fluorophenyl)oxazole-4-carboxylate

There total 7 articles about Methyl 2-(4-fluorophenyl)oxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 5680-80-8
methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride

: 459-57-4
4-fluorobenzaldehyde

: 1065102-64-8
methyl 2-(4-fluorophenyl)-1,3-oxazole-4-carboxylate

Guidance literature:: methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride; 4-fluorobenzaldehyde; With potassium carbonate; In N,N-dimethyl acetamide; at 20 ℃; for 12h;

With Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl acetamide; at 0 - 20 ℃; for 12h;
DOI:10.1021/ol101346w

Reference yield: 70.0%

: 459-57-4
4-fluorobenzaldehyde

: 5619-04-5
methyl 2-amino-3-hydroxypropanoate hydrochloride

: 1065102-64-8
methyl 2-(4-fluorophenyl)-1,3-oxazole-4-carboxylate

Guidance literature:: 4-fluorobenzaldehyde; methyl 2-amino-3-hydroxypropanoate hydrochloride; With potassium carbonate; In N,N-dimethyl acetamide; at 20 ℃; for 12h;

With Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl acetamide; at 0 - 20 ℃; for 12h;
DOI:10.1016/j.bmcl.2015.09.072

Reference yield: 69.6%

: 75-62-7
Bromotrichloromethane

: 5680-80-8
methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride

: 459-57-4
4-fluorobenzaldehyde

: 1065102-64-8
methyl 2-(4-fluorophenyl)-1,3-oxazole-4-carboxylate

Guidance literature:: methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride; 4-fluorobenzaldehyde; With potassium carbonate; In N,N-dimethyl acetamide; at 20 ℃; for 12h;

Bromotrichloromethane; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl acetamide; at 0 - 20 ℃; for 12h;