cyclohexanesulfonic acid [2-methyl-5-(4-methyl-6-morpholin-4-ylpyrimidin-5-ylethynyl)-pyridin-3-yl]-amide

Base Information

Chemical Name:cyclohexanesulfonic acid [2-methyl-5-(4-methyl-6-morpholin-4-ylpyrimidin-5-ylethynyl)-pyridin-3-yl]-amide
CAS No.:1391978-33-8
Molecular Formula:C₂₃H₂₉N₅O₃S
Molecular Weight:455.581
Hs Code.:

Synonyms:cyclohexanesulfonic acid [2-methyl-5-(4-methyl-6-morpholin-4-ylpyrimidin-5-ylethynyl)-pyridin-3-yl]-amide

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Chemical Property of cyclohexanesulfonic acid [2-methyl-5-(4-methyl-6-morpholin-4-ylpyrimidin-5-ylethynyl)-pyridin-3-yl]-amide

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Technology Process of cyclohexanesulfonic acid [2-methyl-5-(4-methyl-6-morpholin-4-ylpyrimidin-5-ylethynyl)-pyridin-3-yl]-amide

There total 12 articles about cyclohexanesulfonic acid [2-methyl-5-(4-methyl-6-morpholin-4-ylpyrimidin-5-ylethynyl)-pyridin-3-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1391979-33-1
2-methyl-5-(4-methyl-6-morpholin-4-ylpyrimidin-5-ylethynyl)pyridin-3-ylamine

: 4837-38-1
cyclohexanesulfonyl chloride

: 1391978-33-8
cyclohexanesulfonic acid [2-methyl-5-(4-methyl-6-morpholin-4-ylpyrimidin-5-ylethynyl)-pyridin-3-yl]-amide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃;

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1391978-33-8
cyclohexanesulfonic acid [2-methyl-5-(4-methyl-6-morpholin-4-ylpyrimidin-5-ylethynyl)-pyridin-3-yl]-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 2 h / 0 - 50 °C

2.1: hydrogenchloride / water / 3 h / Reflux

3.1: ammonium chloride; iron / ethanol / 3 h / Reflux

4.1: diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 100 °C / Inert atmosphere

5.1: potassium carbonate; methanol / 3 h / 20 °C

6.1: diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / dimethyl sulfoxide / 65 °C / Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; 1-methyl-pyrrolidin-2-one / 80 °C

8.1: pyridine / dichloromethane / 20 °C

With pyridine; hydrogenchloride; methanol; iron; sodium hydride; potassium carbonate; ammonium chloride; diisopropylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 911434-04-3
2-(5-bromo-3-nitro-pyridin-2-yl)-malonic acid diethyl ester

: 1391978-33-8
cyclohexanesulfonic acid [2-methyl-5-(4-methyl-6-morpholin-4-ylpyrimidin-5-ylethynyl)-pyridin-3-yl]-amide

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride / water / 3 h / Reflux

2: ammonium chloride; iron / ethanol / 3 h / Reflux

3: diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 100 °C / Inert atmosphere

4: potassium carbonate; methanol / 3 h / 20 °C

5: diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / dimethyl sulfoxide / 65 °C / Inert atmosphere

6: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; 1-methyl-pyrrolidin-2-one / 80 °C

7: pyridine / dichloromethane / 20 °C

With pyridine; hydrogenchloride; methanol; iron; potassium carbonate; ammonium chloride; diisopropylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; dimethyl sulfoxide;