biphenyl-4-carboxylic acid [4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-amide

Base Information

• Chemical Name: biphenyl-4-carboxylic acid [4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-amide
• CAS No.: 1027495-83-5
• Molecular Formula: C₂₆H₂₀N₄O
• Molecular Weight: 404.471

Synonyms:biphenyl-4-carboxylic acid [4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-amide

Chemical Property of biphenyl-4-carboxylic acid [4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-amide

Chemical Property:

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Technology Process of biphenyl-4-carboxylic acid [4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-amide

There total 4 articles about biphenyl-4-carboxylic acid [4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

biphenyl-4-carboxylic acid [4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-amide (1027566-16-0) → biphenyl-4-carboxylic acid [4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-amide (1027495-83-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; at 80 ℃; for 16h;

DOI:10.1016/j.ejmech.2006.03.014

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → biphenyl-4-carboxylic acid [4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-amide (1027495-83-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 47 percent / polyphosphoric acid / xylene / 60 - 150 °C

2: pyridine / 3 h / 20 °C

3: H₂ / Pd/C / methanol; tetrahydrofuran / 16 h / 80 °C

With pyridine; PPA; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; xylene;

DOI:10.1016/j.ejmech.2006.03.014

Reference yield:

4-Nitrophenylene-1,2-diamine (99-56-9) → biphenyl-4-carboxylic acid [4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-amide (1027495-83-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 47 percent / polyphosphoric acid / xylene / 60 - 150 °C

2: pyridine / 3 h / 20 °C

3: H₂ / Pd/C / methanol; tetrahydrofuran / 16 h / 80 °C

With pyridine; PPA; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; xylene;

DOI:10.1016/j.ejmech.2006.03.014

upstream raw materials:

biphenyl-4-carboxylic acid [4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-amide

4-amino-benzoic acid

4-Nitrophenylene-1,2-diamine

5⁽⁶⁾-nitro 2-(4-aminophenyl)-1H-benzimidazole

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