1-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-2-(5-methyl-4-nitroisoxazol-3-yl)ethanone

Base Information

Chemical Name:1-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-2-(5-methyl-4-nitroisoxazol-3-yl)ethanone
CAS No.:1360706-09-7
Molecular Formula:C₂₃H₂₂F₂N₄O₄
Molecular Weight:456.449
Hs Code.:

Synonyms:1-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-2-(5-methyl-4-nitroisoxazol-3-yl)ethanone

Suppliers and Price of 1-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-2-(5-methyl-4-nitroisoxazol-3-yl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-2-(5-methyl-4-nitroisoxazol-3-yl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-2-(5-methyl-4-nitroisoxazol-3-yl)ethanone

There total 8 articles about 1-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-2-(5-methyl-4-nitroisoxazol-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₆H₅ClN₂O₄

: 27469-60-9
1-(4-fluorophenyl)methyl-piperazine

: 1360706-09-7
1-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-2-(5-methyl-4-nitroisoxazol-3-yl)ethanone

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2011.09.047

Reference yield:

: 365-24-2
4,4'-difluorobenzhydryl alcohol

: 1360706-09-7
1-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-2-(5-methyl-4-nitroisoxazol-3-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

2: acetonitrile / Reflux

3: triethylamine / dichloromethane

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2011.09.047

Reference yield:

: 345-92-6
4,4'-Difluorobenzophenone

: 1360706-09-7
1-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-2-(5-methyl-4-nitroisoxazol-3-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / 0 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

3: acetonitrile / Reflux

4: triethylamine / dichloromethane

With sodium tetrahydroborate; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2011.09.047