(-)-(E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolane-2-ylidene]-1H-imidazol-1-acetonitrile

Base Information

Chemical Name:(-)-(E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolane-2-ylidene]-1H-imidazol-1-acetonitrile
CAS No.:256424-63-2
Molecular Formula:C₁₄H₉Cl₂N₃S₂
Molecular Weight:354.284
Hs Code.:

Synonyms:(-)-(E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolane-2-ylidene]-1H-imidazol-1-acetonitrile

Suppliers and Price of (-)-(E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolane-2-ylidene]-1H-imidazol-1-acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-Luliconazole
100mg
$ 1325.00

Crysdot
(S,E)-2-(4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene)-2-(1H-imidazol-1-yl)acetonitrile 97%
1g
$ 680.00

Alichem
(S,E)-2-(4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene)-2-(1H-imidazol-1-yl)acetonitrile
1g
$ 680.00

Total 9 raw suppliers

Chemical Property of (-)-(E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolane-2-ylidene]-1H-imidazol-1-acetonitrile

Chemical Property:

Melting Point:143-146oC
Boiling Point:499.1±55.0 °C(Predicted)
Density:1.52±0.1 g/cm3(Predicted)

Purity/Quality:

> 95% ^*data from raw suppliers

(S)-Luliconazole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (S)-Luliconazole is the (S)--enantiomer of Luliconazole, an azole antifungal drug. Luliconazole was found to interfere with ergosterol biosynthesis in cell-free extracts of Candida albican, while no interference due to (S)-Luliconazole was found.

Technology Process of (-)-(E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolane-2-ylidene]-1H-imidazol-1-acetonitrile

There total 5 articles about (-)-(E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolane-2-ylidene]-1H-imidazol-1-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: (E)-(4S)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene(1H-imidazol-1-yl)acetonitrile hemifumarate

: 256424-63-2,187164-19-8
(-)-(E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolane-2-ylidene]-1H-imidazol-1-acetonitrile

Guidance literature:: With water; sodium hydroxide; at 40 ℃; for 0.333333h;

Reference yield: 40.0%

: 23184-45-4
2-cyanomethyl-imidazole

: 229334-55-8
(S)-2-chloro-1-(2,4-dichlorophenyl)ethyl methanesulfonate

: 256424-63-2,187164-19-8
(-)-(E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolane-2-ylidene]-1H-imidazol-1-acetonitrile

Guidance literature:: 2-cyanomethyl-imidazole; With carbon disulfide; sodium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 5h;

(S)-2-chloro-1-(2,4-dichlorophenyl)ethyl methanesulfonate; In dimethyl sulfoxide; at 20 ℃;